Effects of Kangquan Recipe (sic) on Sex Steroids and Cell Proliferation in Rats with Benign Prostatic Hyperplasia

CORC > 厦门大学 > 海洋环境－已发表论文

	Effects of Kangquan Recipe (sic) on Sex Steroids and Cell Proliferation in Rats with Benign Prostatic Hyperplasia
	Huang Yuan-peng ; Du Jian ; Hong Zhen-feng ; Chen Zhi-qing ; Wu Jin-fa ; Zhao Jin-yan ; Huang YP(黄奕普)
刊名	http://dx.doi.org/10.1007/s11655-009-0289-3
	2009-08
关键词	Kangquan Recipe benign prostatic hyperplasia testosterone estradiol cell proliferation
英文摘要	Foundation of Traditional Chinese Medicine of Fujian Province [wzy0616]; Foundation of Key Projects from Science and Technology Department of Fujian Province [2008Y0049]; Foundation of Science and Technology Department of Xiamen [3502Z20084014]; Objective: To investigate the effects of Kangquan Recipe (sic, KQR) on sex steroids and cell proliferation in an experimental benign prostatic hyperplasia (BPH) model in rats. Methods: Seventy-two SD rats were randomly divided into six groups: the normal group, the model group, the finasteride group, and the low-, middle-, and high-dose KQR groups, 12 in each group. Except those in the normal group, the rats were injected with testosterone after castration for the establishment of BPH model and then given respectively with normal saline, finasteride, and low-, middle-, and high-dose of KOR for 30 days. The levels of plasma testosterone (T) and estradiol (E(2)) were determined by enzyme-linked immunosorbent assay (ELISA), and the mRNA expression of proliferating cell nuclear antigen (PCNA) in prostate tissue was detected by reverse transcription-polymerase chain reaction (RT-PCR) after administration. Results: Compared with the model group, the prostate weight, the plasma T, and the mRNA expression of PCNA were significantly lower, and the plasma E(2) and the ratio of E(2)/T were higher in the three KQR groups (P<0.05 or P<0.01). There was no significant difference in the prostate weight, plasma T and E2, and ratio of E2/T among the finasteride group and the three KQR groups (P>0.05). The mRNA expressions of PCNA were significantly higher in the middle- and low-dose of KOR groups than those in the finasteride group (P<0.05). Conclusion: KQR shows multitarget effects on experimental BPH rats, and the mechanism might be related with regulating the balance of plasma T and E(2) and decreasing the PCNAmRNA expression in prostate tissue to restrain cell proliferation in a dose-dependent manner.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/60952]
专题	海洋环境－已发表论文
推荐引用方式 GB/T 7714	Huang Yuan-peng,Du Jian,Hong Zhen-feng,et al. Effects of Kangquan Recipe (sic) on Sex Steroids and Cell Proliferation in Rats with Benign Prostatic Hyperplasia[J]. http://dx.doi.org/10.1007/s11655-009-0289-3,2009.
APA	Huang Yuan-peng.,Du Jian.,Hong Zhen-feng.,Chen Zhi-qing.,Wu Jin-fa.,...&黄奕普.(2009).Effects of Kangquan Recipe (sic) on Sex Steroids and Cell Proliferation in Rats with Benign Prostatic Hyperplasia.http://dx.doi.org/10.1007/s11655-009-0289-3.
MLA	Huang Yuan-peng,et al."Effects of Kangquan Recipe (sic) on Sex Steroids and Cell Proliferation in Rats with Benign Prostatic Hyperplasia".http://dx.doi.org/10.1007/s11655-009-0289-3 (2009).