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	Neurotoxins from marine dinoflagellates: A brief review
	Wang, Da-Zhi ; Wang DZ(王大志)
	2008-06
关键词	dinoflagellates voltage-gated ion channels molecular action mechanism paralytic shellfish poisoning neurotoxic shellfish poisoning ciguatera fish poisoning azaspiracid poisoning yessotoxin palytoxin neurotoxins
英文摘要	Dinoflagellates are not only important marine primary producers and grazers, but also the major causative agents of harmful algal blooms. It has been reported that many dinoflagellate species can produce various natural toxins. These toxins can be extremely toxic and many of them are effective at far lower dosages than conventional chemical agents. Consumption of seafood contaminated by algal toxins results in various seafood poisoning syndromes: paralytic shellfish poisoning (PSP), neurotoxic shellfish poisoning (NSP), amnesic shellfish poisoning (ASP), diarrheic shellfish poisoning (DSP), ciguatera fish poisoning (CFP) and azaspiracid shellfish poisoning (ASP). Most of these poisonings are caused by neurotoxins which present themselves with highly specific effects on the nervous system of animals, including humans, by interfering with nerve impulse transmission. Neurotoxins are a varied group of compounds, both chemically and pharmacologically. They vary in both chemical structure and mechanism of action, and produce very distinct biological effects, which provides a potential application of these toxins in pharmacology and toxicology. This review summarizes the origin, structure and clinical symptoms of PSP, NSP, CFP, AZP, yessotoxin and palytoxin produced by marine dinoflagellates, as well as their molecular mechanisms of action on voltage-gated ion channels.
语种	英语
出版者	MOLECULAR DIVERSITY PRESERVATION INT
内容类型	期刊论文
源URL	[http://dx.doi.org/10.3390/md20080016]
专题	海洋环境－已发表论文
推荐引用方式 GB/T 7714	Wang, Da-Zhi,Wang DZ. Neurotoxins from marine dinoflagellates: A brief review[J],2008.
APA	Wang, Da-Zhi,&王大志.(2008).Neurotoxins from marine dinoflagellates: A brief review..
MLA	Wang, Da-Zhi,et al."Neurotoxins from marine dinoflagellates: A brief review".(2008).

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