A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats

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	A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats
	Zhao, Liang-Cai ; Zhang, Xiao-Dong ; Liao, Shi-Xian ; Gao, Hong-Chang ; Wang, He-Yao ; Lin, Dong-Hai ; Lin DH(林东海) ; Lin DH(林东海)
刊名	http://dx.doi.org/10.1155/2010/431894
	2010
关键词	DEPENDENT DIABETES-MELLITUS OBESE FA/FA ZUCKER GLUCOSE-TRANSPORT GOTO-KAKIZAKI LIVER METABOLISM PLASMA HEPATOTOXICITY DYSFUNCTION TOXICITY
英文摘要	National Natural Science Foundation of China [20705037, 30730026]; Medicine & Health Special Foundation of Zhejiang Province [2010QNA016]; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program" [2009ZX09301-001]; To further investigate pathogenesis and pathogenic process of type 2 diabetes mellitus (T2DM), we compared the urinary metabolic profiling of Zucker obese and Goto-kakizaki (GK) rats by NMR-based metabonomics. Principal component analysis (PCA) on urine samples of both models rats indicates markedly elevated levels of creatine/creatinine, dimethylamine, and acetoacetate, with concomitantly declined levels of citrate, 2-ketoglurarate, lactate, hippurate, and succinate compared with control rats, respectively. Simultaneously, compared with Zucker obese rats, the GK rats show decreased levels of trimethylamine, acetate, and choline, as well as increased levels of creatine/creatinine, acetoacetate, alanine, citrate, 2-ketoglutarate, succinate, lactate, and hippurate. This study demonstrates metabolic similarities between the two stages of T2DM, including reduced tricarboxylic acid (TCA) cycle and increased ketone bodies production. In addition, compared with Zucker obese rats, the GK rats have enhanced concentration of energy metabolites, which indicates energy metabolic changes produced in hyperglycemia stage more than in insulin resistance stage.
语种	英语
出版者	J BIOMED BIOTECHNOL
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/87531]
专题	公共事务－已发表论文
推荐引用方式 GB/T 7714	Zhao, Liang-Cai,Zhang, Xiao-Dong,Liao, Shi-Xian,et al. A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats[J]. http://dx.doi.org/10.1155/2010/431894,2010.
APA	Zhao, Liang-Cai.,Zhang, Xiao-Dong.,Liao, Shi-Xian.,Gao, Hong-Chang.,Wang, He-Yao.,...&林东海.(2010).A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats.http://dx.doi.org/10.1155/2010/431894.
MLA	Zhao, Liang-Cai,et al."A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats".http://dx.doi.org/10.1155/2010/431894 (2010).