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氨基葡萄糖基吡啶基脲类化合物的合成; The synthesis of glucosamine pyridylureas derivates
陈宇 ; 洪碧红 ; 黄文文 ; 陈永强 ; 易瑞灶
2014-06-15
关键词氨基葡萄糖盐酸盐 氨基吡啶 糖基吡啶基脲 D-glucosamine hydrochloride aminopyridine sugar pridylureas
英文摘要目的设计简便高效的合成路线,合成新型糖基吡啶基脲类化合物。方法采用异氰酸酯法,以d-氨基葡萄糖盐酸盐为原料,乙酰化合成1,3,4,6-四-O-乙酰基-α-d-氨基葡萄糖硫酸盐,在三光气的作用下与氨基吡啶反应得到糖基吡啶基脲,并用Ir、1 H nMr、13 C nMr及质谱对合成样品进行表征。结果得到了6个未见文献报导的糖基吡啶基脲类化合物,且确证了6个新化合物的结构。结论该合成方法工艺简单,操作易行,进一步发展了异氰酸酯法的脲合成,可望用来合成一系列含取代基的糖基吡啶基脲类物质。; Objective To create a convenient and efficient synthetic route to get new sugar pyridylureas.Methods 1,3,4,6-tetra-O-acetyl-α-D-glucosamine sulfate was prepared by direct acetylation of D-glucosamine hydrochloride with acetic anhydride.Glucosamine pyridylureas derivates could be prepared by using the method of isocyanate.The products were identified by IR,1 H NMR,13 C NMR and MS.Results Six new sugar pyridylureas were prepared and their structures were confirmed.Conclusion This synthetic method can be expected to synthesize a series of sugar pyridylureas containing substituting group on the sugar ring.It is indicated that the synthetic method is simple and very easy to operate.; 海洋公益性行业科研专项(201405016)资助
语种zh_CN
内容类型期刊论文
源URL[http://dspace.xmu.edu.cn/handle/2288/98450]  
专题材料学院-已发表论文
推荐引用方式
GB/T 7714
陈宇,洪碧红,黄文文,等. 氨基葡萄糖基吡啶基脲类化合物的合成, The synthesis of glucosamine pyridylureas derivates[J],2014.
APA 陈宇,洪碧红,黄文文,陈永强,&易瑞灶.(2014).氨基葡萄糖基吡啶基脲类化合物的合成..
MLA 陈宇,et al."氨基葡萄糖基吡啶基脲类化合物的合成".(2014).
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