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	替莫唑胺聚氰基丙烯酸正丁酯纳米粒的制备; Preparation of temozolomide-loaded polybutylcyanoacrylate nanoparticles
	田新华 ; 林晓宁 ; 魏峰 ; 丰伟 ; 黄志纯 ; 王鹏 ; 任磊 ; 刁艺
	2011
关键词	替莫唑胺 聚氰基丙烯酸正丁酯 纳米粒 正交设计 temozolomide polybutylcyanoacrylate nanoparticles orthogonal design
英文摘要	目的:优化工艺制备替莫唑胺聚氰基丙烯酸正丁酯纳米粒(TMz-PbCA-nP)。方法:以α-氰基丙烯酸正丁酯(bCA)为载体,采用乳化聚合法制备TMz-PbCA-nP,并以PlurOnICf-68作为表面活性剂,通过考察粒径大小和包封率2个指标,在单因素实验初选的基础上,正交设计法优化处方和制备工艺。结果:制备TMz-PbCA-nP的优化条件为反应体系PH2.5,用1%PlurOnICf-68作为表面活性剂,TMz用量5 Mg,bCA单体用量0.1 Ml,按优化条件所制备的TMz-PbCA-nP平均粒径(135.8±11.3)nM,多分散系数为0.19,表面电位(-24.8±2.2)MV,包封率(44.23±2.04)%,载药量(2.80±0.05)%。结论:通过优化处方和制备工艺,采用乳化聚合法可制备出TMz-PbCA-nP,对拓展TMz临床给药新剂型提供一定的参考。; OBJECTIVE To prepare temozolomide polybutylcyanoacrylate nanoparticles(TMZ-PBCA-NP) with optimized process.METHODS TMZ-PBCA-NP was prepared by emulsion polymerization with the α-butylcyanoacrylate(BCA) as its carrier and the surface of the nanoparticles was modified with PluronicF-68.Single factor test and orthogonal design were carried out to optimize the preparing technology according to the particle size and the entrapment efficiency of TMZ-PBCA-NP.RESULTS The optimal conditions for the preparation of TMZ-PBCA-NP was pH 2.5,1.0% PluronicF-68(w/v),0.1 mL BCA monomer and 5 mg temozolomide;on the basis of the above conditions,the mean particle size of the NP was(135.8±11.3)nm and the polydispersity index(PDI) was 0.19,the surface charge was(-24.8±2.2)mV,the average entrapment efficiency and drug loading was(44.23±2.04)% and(2.80±0.05)%,respectively.CONCLUSION An optimized nanoparticle drug delivery system is obtained by emulsion polymerization and it provides a new direction for temozolomide dosage forms in clinic.; 福建省自然科学基金项目(编号:2006J0188);厦门市科技局基金项目(编号:3502Z20064013)
语种	zh_CN
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/98384]
专题	材料学院－已发表论文
推荐引用方式 GB/T 7714	田新华,林晓宁,魏峰,等. 替莫唑胺聚氰基丙烯酸正丁酯纳米粒的制备, Preparation of temozolomide-loaded polybutylcyanoacrylate nanoparticles[J],2011.
APA	田新华.,林晓宁.,魏峰.,丰伟.,黄志纯.,...&刁艺.(2011).替莫唑胺聚氰基丙烯酸正丁酯纳米粒的制备..
MLA	田新华,et al."替莫唑胺聚氰基丙烯酸正丁酯纳米粒的制备".(2011).

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