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	明胶-硅氧烷多孔支架材料原位诱导兔颅骨再生的实验研究; Experimental study of using GSPS for in situ osteogenesis induction on rabbit skull
	杨芳裕 ; 康江河 ; 王军 ; 任磊
	2010
关键词	颅骨缺损 明胶-硅氧烷多孔支架材料 BMP-2 Bone defect Gelatin-siloxane-Ca (NO3) 2 porous scaffolds BMP-2
英文摘要	目的:研究明胶-硅氧烷多孔支架材料混合多种材料用以原位诱导兔颅骨再生的效果。方法:采用可降解、具有双孔径的明胶-硅氧烷多孔支架材料,并复合bMP2和兔骨髓间充质干细胞,在去骨瓣减压手术时将材料置于骨窗上,同时采用空白对照来探讨兔颅骨原位诱导再生。用高速螺旋CT扫描颅骨并三维重建来测量颅骨缺损的愈合情况,并作出比较。结果:支架材料+bMP组动物的颅骨修复率与支架材料+红骨髓组动物的修复率相当(P=0.43);支架材料+红骨髓组动物的颅骨修复率高于单纯支架材料组动物的修复率(P=0.01);单纯支架材料组动物的颅骨修复率与空白对照组动物的修复率无明显差别(P=0.18)。结论:明胶-硅氧烷-CA(nO3)2多孔复合支架材料分别与bMP以及红骨髓混合使用能够明显提高颅骨缺损的骨愈合速度以及修复率;而单纯使用支架材料并不能促进实验动物的颅骨修复。; Objective:To investigate the effect of using GSPS for in situ osteogenesis induction on rabbit skull.Methods:The biodegradable,with double-aperture gelatin -siloxane porous scaffold materials was mixed with BMP2 or rabbit bone marrow mesenchymal stem cells to fix the skull bone deficit after craniectomy decompression.A blank control was set to compare with the effect of in situ osteogenesis of rabbit skull.High-speed spiral CT scanning and three-dimensional reconstruction of the skull was performed to inspect the healing progress of skull defects.Results:The GSPS + BMP group had the equal bone healing rate as the GSPS+ bone marrow group (P=0.43); and the GSPS + bone marrow group had the higher bone healing rate than the GSPS group (P =0.01).There were no significant difference on bone healing rate between GSPS group and blank control group (P=0.18).Conclusion:Gelatin-siloxane-Ca (NO3) 2 porous scaffolds could be used with the BMP,as well as red bone marrow to improve the bone healing of skull bone defect while no significant effect could be observed using GSPS solely.
语种	zh_CN
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/98361]
专题	材料学院－已发表论文
推荐引用方式 GB/T 7714	杨芳裕,康江河,王军,等. 明胶-硅氧烷多孔支架材料原位诱导兔颅骨再生的实验研究, Experimental study of using GSPS for in situ osteogenesis induction on rabbit skull[J],2010.
APA	杨芳裕,康江河,王军,&任磊.(2010).明胶-硅氧烷多孔支架材料原位诱导兔颅骨再生的实验研究..
MLA	杨芳裕,et al."明胶-硅氧烷多孔支架材料原位诱导兔颅骨再生的实验研究".(2010).

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