| 乙酰普鲁兰纳米粒的制备; Preparation of pullulan acetate nanoparticles | |
| 张慧珠 ; 刘玲蓉 ; 张其清 | |
| 2009 | |
| 关键词 | 普鲁兰多糖 乙酰普鲁兰 溶剂扩散法 纳米粒 pullulan pullulan acetate solvent diffusion method nanoparticle |
| 英文摘要 | 目的:通过乙酰化反应将亲水性普鲁兰多糖进行疏水改性,并制备乙酰普鲁兰纳米粒。方法:利用傅立叶红外光谱(fOurIEr TrAnSfOrMInfrArEd,fT-Ir)、核磁共振氢谱(PrOTOn nuClEAr MAgnETIC rESOnAnCE,1HnMr)对乙酰普鲁兰结构进行表征并计算乙酰化取代度。采用溶剂扩散法制备乙酰化普鲁兰纳米粒,并通过透射电镜及动态光散射仪表征了纳米粒的形态和粒径,以考察各种因素对纳米粒形成的影响。结果:fT-Ir及1H nMr结果证明乙酰化产物的存在;乙酰普鲁兰纳米粒为球形,粒径随乙酰基取代度的增加而增加。结论:可通过溶剂扩散法制备乙酰普鲁兰纳米粒,该方法简单易行,易于扩大生产。该纳米粒有望成为新型纳米药物载体。; Objective:To synthesize pullulan acetate(PA) by the reaction of pullulan with acetic anhydride and prepare its nanoparticles.Methods:The chemical structure of product was characterized by Fourier transform infrared(FT-IR) and proton nuclear magnetic resonance(1H NMR) spectroscopy.The degree of substitution was determined by 1H NMR.The solvent diffusion method was used to prepare PA nanoparticles.The nanoparticles were analyzed by transmission electron microscopy(TEM),dynamic laser light scattering(DLLS) to investigate influencing factors.Results:The chemical structure of PA was confirmed by FT-IR and 1H NMR.PA nanoparticles had spherical morphology and the size was increased with acetate degree of substitution.Conclusion:PA nanoparticles could be prepared by solvent diffusion method.The preparation procedure was easy for industrial production.This novel nanoparticle system was promising to be a good drug carrier.; 国家重大科学研究计划项目(2006CB933300);博士点基金项目(20060023050) |
| 语种 | zh_CN |
| 内容类型 | 期刊论文 |
| 源URL | [http://dspace.xmu.edu.cn/handle/2288/98344]  |
| 专题 | 材料学院－已发表论文 |
| 推荐引用方式 GB/T 7714 | 张慧珠,刘玲蓉,张其清. 乙酰普鲁兰纳米粒的制备, Preparation of pullulan acetate nanoparticles[J],2009. |
| APA | 张慧珠,刘玲蓉,&张其清.(2009).乙酰普鲁兰纳米粒的制备.. |
| MLA | 张慧珠,et al."乙酰普鲁兰纳米粒的制备".(2009). |
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