Novel methotrexate prodrug-targeted drug delivery system based on PEG-lipid-PLA hybrid nanoparticles for enhanced anticancer efficacy and reduced toxicity of mitomycin C

CORC > 厦门大学 > 材料学院－已发表论文

	Novel methotrexate prodrug-targeted drug delivery system based on PEG-lipid-PLA hybrid nanoparticles for enhanced anticancer efficacy and reduced toxicity of mitomycin C
	Li, Yang ; Lin, Jinyan ; Wu, Hongjie ; Jia, Mengmeng ; Yuan, Conghui ; Chang, Ying ; Hou, Zhenqing ; Dai, Lizong ; Hou ZQ(侯振清) ; Dai LZ(戴李宗)
刊名	http://dx.doi.org/10.1039/c4tb00499j
	2014
关键词	Drug products Emulsification Encapsulation Particle size Particle size analysis
英文摘要	In the present study we have investigated novel MTX prodrug-targeted and MMC-loaded PLA-lipid-PEG hybrid NPs. These employ a double emulsion solvent evaporation method for the introduction of an anticancer drugs moiety of the MMC-soybean phosphatidylcholine complex or DSPE-PEG-MTX, in which the MTX prodrug can be exploited as a targeting ligand. The prepared drug delivery systems present a spherical shape, a small particle size (219.6 ± 2.1 nm) with narrow particle size distribution, high MMC encapsulation efficiency (90.5 ± 3.0%) and a sustained and pH-controlled MMC release. The advantage of the new drug delivery systems is that the two-anticancer drug moiety can coordinate the early-phase targeting effect with the later-phase anticancer effect. In vivo pharmacokinetics, following intravenous administration of the drug delivery systems, indicates a prolonged systemic circulation time of MMC. More importantly, the drug delivery systems exhibited a significant accumulation of MMC in the nuclei as the site of MMC action, which was indicative of the enhancement of anticancer activity. Such a design of drug delivery systems may open up a new horizon for targeted delivery and sustained and controlled release of MMC. This journal is ? the Partner Organisations 2014.
语种	英语
出版者	Royal Society of Chemistry
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/87429]
专题	材料学院－已发表论文
推荐引用方式 GB/T 7714	Li, Yang,Lin, Jinyan,Wu, Hongjie,et al. Novel methotrexate prodrug-targeted drug delivery system based on PEG-lipid-PLA hybrid nanoparticles for enhanced anticancer efficacy and reduced toxicity of mitomycin C[J]. http://dx.doi.org/10.1039/c4tb00499j,2014.
APA	Li, Yang.,Lin, Jinyan.,Wu, Hongjie.,Jia, Mengmeng.,Yuan, Conghui.,...&戴李宗.(2014).Novel methotrexate prodrug-targeted drug delivery system based on PEG-lipid-PLA hybrid nanoparticles for enhanced anticancer efficacy and reduced toxicity of mitomycin C.http://dx.doi.org/10.1039/c4tb00499j.
MLA	Li, Yang,et al."Novel methotrexate prodrug-targeted drug delivery system based on PEG-lipid-PLA hybrid nanoparticles for enhanced anticancer efficacy and reduced toxicity of mitomycin C".http://dx.doi.org/10.1039/c4tb00499j (2014).