Microwave-assisted synthesis of poly(epsilon-caprolactone) with acid as initiator and a novel method in preparation of drug release systems | |
Song, Y. ; Liu, L. J. ; Yu, Z. J. ; Weng, X. C. ; Zhuo, R. X. ; Yu ZJ(余兆菊) | |
2003 | |
英文摘要 | Acid-initiated ring-opening polymerization (ROP) of epsilon-caprolactone (epsilon-CL) was performed under microwave irradiation without metallic catalysts. Poly(epsilon-caprolactone) (PCL) with weight-average molar mass (Mw) over 12000 g/mol and Mw/Mn below 1.6 was synthesized in the presence of carboxylic acids such as maleic acid (MA), succinic acid and adipic acid. The effects of microwave power, irradiation time, epsilon-CL/acid molar ratio and acidity of acid on the polymerization were investigated. Both the rate of polymerization and molar mass of the obtained polymer were enhanced in comparison with conventional thermal method. As a new treatment, PCL-based drug controlled release system was obtained directly by microwave-assisted ROP of epsilon-CL mixed with ibuprofen (IBU) initiated by MA. The release of IBU from the system was sustained from 12 h to 9 days with IBU content in weight from 5 to 20%. It seems that this is a promising method to prepare drug controlled release systems. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/59022] ![]() |
专题 | 材料学院-已发表论文 |
推荐引用方式 GB/T 7714 | Song, Y.,Liu, L. J.,Yu, Z. J.,et al. Microwave-assisted synthesis of poly(epsilon-caprolactone) with acid as initiator and a novel method in preparation of drug release systems[J],2003. |
APA | Song, Y.,Liu, L. J.,Yu, Z. J.,Weng, X. C.,Zhuo, R. X.,&余兆菊.(2003).Microwave-assisted synthesis of poly(epsilon-caprolactone) with acid as initiator and a novel method in preparation of drug release systems.. |
MLA | Song, Y.,et al."Microwave-assisted synthesis of poly(epsilon-caprolactone) with acid as initiator and a novel method in preparation of drug release systems".(2003). |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论