Blood-brain barrier transport of Tat peptide and polyethylene glycol decorated gelatin-siloxane nanoparticle

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	Blood-brain barrier transport of Tat peptide and polyethylene glycol decorated gelatin-siloxane nanoparticle
	Tian, Xin-hua ; Wei, Feng ; Wang, Tian-xiao ; Wang, Dong ; Wang, Jun ; Lin, Xiao-ning ; Wang, Peng ; Ren, Lei ; Ren L(任磊)
刊名	http://dx.doi.org/10.1016/j.matlet.2011.10.042
	2012-02-01
关键词	DRUG CARRIER DELIVERY CANCER CNS
英文摘要	National Natural Science Foundation of China [30970733, 81171448, 81172394]; National Basic Research Program of China [2010CB732402]; Contemporary treatment of brain diseases has been hampered by limited drug delivery across the blood-brain barrier (BBB). Herein, gelatin-siloxane nanoparticles (GSNPs) with controlled size and surface charge were synthesized through a two-step sol-gel process. In order to increase the efficiency of brain targeting, HIV-derived Tat peptide and PEG were further grafted onto GS NPs (Tat-PEG-GS NPs). In vivo imaging and TEM results indicated Tat-PEG-GS NPs could not only escape the capture by reticulo-endothelial system but also cross BBB and reach central nervous system of mice. Hence, Tat-PEG-GS NPs might represent a new type of non-viral vector for the delivery of drug or therapeutic DNA to brain by crossing BBB. (c) 2011 Elsevier B.V. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/58992]
专题	材料学院－已发表论文
推荐引用方式 GB/T 7714	Tian, Xin-hua,Wei, Feng,Wang, Tian-xiao,et al. Blood-brain barrier transport of Tat peptide and polyethylene glycol decorated gelatin-siloxane nanoparticle[J]. http://dx.doi.org/10.1016/j.matlet.2011.10.042,2012.
APA	Tian, Xin-hua.,Wei, Feng.,Wang, Tian-xiao.,Wang, Dong.,Wang, Jun.,...&任磊.(2012).Blood-brain barrier transport of Tat peptide and polyethylene glycol decorated gelatin-siloxane nanoparticle.http://dx.doi.org/10.1016/j.matlet.2011.10.042.
MLA	Tian, Xin-hua,et al."Blood-brain barrier transport of Tat peptide and polyethylene glycol decorated gelatin-siloxane nanoparticle".http://dx.doi.org/10.1016/j.matlet.2011.10.042 (2012).