新型多吡啶配体的设计及其对配合物与DNA作用机制的影响

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	新型多吡啶配体的设计及其对配合物与DNA作用机制的影响
	张黔玲 ; 刘剑洪 ; 刘建忠 ; 任祥忠 ; 张培新 ; 魏波 ; 徐宏 ; 计亮年
刊名	http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=GDXH200310005&dbname=CJFQ2003
	2012-04-27 ; 2012-04-27
关键词	多吡啶钌配合物 DNA 插入作用沟面结合
中文摘要	Two structurally related polypyridyl ligands ODHIP(3,4-dihydroxyl-imidazophenanthroline), MDHIP(2,4-dihydroxyl-imidazo phenanthroline) and their ruthenium(II) complexes [Ru(phen) 2ODHIP] 2+ and [Ru(phen) 2MDHIP] 2+ were prepared and characterized. Their DNA-binding properties were studied by spectroscopic methods and viscosity measurements. The results indicated that the two complexes are bound to DNA by different modes due to the different planarities of ligands. For the complex [Ru(phen) 2MDHIP] 2+, the 2- position ortho group of MDHIP could form an intramolecular hydrogen bond with the nitrogen atom of the imidazole ring to extend the planarity and strengthen the binding affinity. On the other hand, the 4- position ortho group hindered the complex from intercalating into the base pairs of DNA, and finally, making the complex bind to DNA by a partial intercalative mode. However, for the complex [Ru(phen) 2ODHIP] 2+, there was no intramolecular hydrogen bond formed and the two ort...
语种	中文
其他责任者	深圳大学师范学院化学与生物学系 ; 中山大学化学与化工学院 ; 中山大学化学与化工学院深圳518060 ; 深圳518060 ; 广州510275
内容类型	期刊论文
源URL	[http://ir.calis.edu.cn/hdl/244041/368]
专题	深圳大学
推荐引用方式 GB/T 7714	张黔玲,刘剑洪,刘建忠,等. 新型多吡啶配体的设计及其对配合物与DNA作用机制的影响[J]. http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=GDXH200310005&dbname=CJFQ2003,2012, 2012.
APA	张黔玲.,刘剑洪.,刘建忠.,任祥忠.,张培新.,...&计亮年.(2012).新型多吡啶配体的设计及其对配合物与DNA作用机制的影响.http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=GDXH200310005&dbname=CJFQ2003.
MLA	张黔玲,et al."新型多吡啶配体的设计及其对配合物与DNA作用机制的影响".http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=GDXH200310005&dbname=CJFQ2003 (2012).