不同浓度乳酸对家兔离体心室乳头肌收缩力和细胞动作电位的影响

CORC > 集美大学

	不同浓度乳酸对家兔离体心室乳头肌收缩力和细胞动作电位的影响
	刘昭强 ; 史清钊 ; 刘英杰 ; 朱寄天
刊名	http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=tykx200507008&dbcode=CJFQ&dbname=CJFQ2005
	2012-06-05 ; 2012-06-05
关键词	乳酸收缩力乳头肌心肌细胞白兔动物实验 lactate contractile force papillary muscle cardiac cell rabbit animal experiment G804.7
其他题名	Effect of Lactate Solution of Different Concentration on Contractile Force of Rabbit Ventricular Papillary and Cellular Action Potential in Vitro
中文摘要	目的:研究乳酸对家兔离体心室乳头肌收缩力和细胞动作电位的影响。方法:应用细胞内微电极技术和微拉力描记法,研究不同浓度乳酸对家兔离体心室乳头肌收缩力(n=10)、心肌细胞动作电位(n=6)的影响。结果:一定浓度的乳酸对心肌有负性肌力作用,心肌收缩力的降低随乳酸浓度的升高而更趋明显。4mmol/L乳酸溶液灌注后,心肌细胞跨膜电位的变化为Vmax显著降低(P<0.005)。结论:乳酸溶液达4mmol/L时导致0期去极化速度的降低,即Na+通道效率降低。乳酸浓度升高引起心肌收缩力下降,其可能机制为Na+内流减少,Na+-H+交换减少,造成细胞内H+浓度升高;经Na+-Ca2+交换使Ca2+外流减少,导致细胞内Ca2+超载。; To investigate the effect of lactate solution of different concentration on action potential of ventricular papillary muscle cell and contractile force.Through using the intracellular microelectrode technique and micro-tension depicting method,this paper studied the effect of lactate solution of different concentration on action potential of ventricular papillary muscle cell(n=6) and contractile force(n=10).The result showed that effect of lactate solution of certain concentration was obvious after perfuse with lactate solution of 4 mmol/L.The Vmax decreased significantly(P<0.05).It concluded that 4 mmol/L of lactate concentration could lead to decrease of depolarication.The efficiency of Na~+ channel decreased.The elevated lactate concentration leads to decrease of contractile force if cardiac muscle.The possible mechanism was Na~+ influx and Na~+-H~+ exchange was inhibited.It resulted the elevation of intracellular H~+ concentration.Through the Na~+-H~+ exchange,Ca~ 2+ efflux decreased and intracellular Ca~ 2+ overload.; 【作者单位】集美大学体育学院；首都体育学院；成都体育学院福建厦门361021；北京100088；福建厦门361021；四川成都610041；【作者英文名】LIU Zhao-qiang~1,SHI Qing-zhao~2,LIU Ying-jie~1,ZHU Ji-tian~31.Institute of Physical Education,Jimei University,Xiamen 361021,China;2.Capital Institute of Physical Education,Beijing 100088,China;3.Chengdu Institute of Physical Education,Chengdu 61004
语种	中文
内容类型	期刊论文
源URL	[http://ir.calis.edu.cn/hdl/235041/18939]
专题	集美大学
推荐引用方式 GB/T 7714	刘昭强,史清钊,刘英杰,等. 不同浓度乳酸对家兔离体心室乳头肌收缩力和细胞动作电位的影响[J]. http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=tykx200507008&dbcode=CJFQ&dbname=CJFQ2005,2012, 2012.
APA	刘昭强,史清钊,刘英杰,&朱寄天.(2012).不同浓度乳酸对家兔离体心室乳头肌收缩力和细胞动作电位的影响.http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=tykx200507008&dbcode=CJFQ&dbname=CJFQ2005.
MLA	刘昭强,et al."不同浓度乳酸对家兔离体心室乳头肌收缩力和细胞动作电位的影响".http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=tykx200507008&dbcode=CJFQ&dbname=CJFQ2005 (2012).