肝癌组织、外周血淋巴细胞和癌旁组织MRP1的表达对评估原发性肝癌预后的价值比较

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	肝癌组织、外周血淋巴细胞和癌旁组织MRP1的表达对评估原发性肝癌预后的价值比较
	晁鹏丽 ; 张忠英 ; 刘莉莉 ; 陈俊
刊名	http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=lcwk200807011&dbcode=CJFQ&dbname=CJFQ2008
	2012-06-05 ; 2012-06-05
关键词	多药耐药基因1相关糖蛋白原发性肝癌转移复发生存期 MRP1 primary carcinoma of liver metastases relapse life-span R735.7
其他题名	Contrast the clinical value in detecting the expression of mrp1 of pbl and cancerousous tissues and para-carcinoma tissues when predicting the prognosi of primary carcinoma of liver
中文摘要	目的探讨检测肝癌组织、外周血淋巴细胞及癌旁组织的MRP1(多药耐药基因1相关糖蛋白)表达水平在评估以手术为主辅以化疗的原发性肝癌患者复发或转移及生存期中的临床应用价值。方法用流式细胞术同时检测26例初诊原发性肝癌患者外周血淋巴细胞、癌组织和癌旁组织MRP1表达水平,术后对患者进行追踪随访,了解其复发或转移及生存情况,分析三者MRP1的表达与复发或转移及生存期生存率间的关系。结果初次就诊的原发性肝癌患者中,MRP1阳性率分别是肝癌组织61.5%,其次是外周血淋巴细胞53.8%、癌旁组织50.0%,但三者间并差异无统计学意义(P>0.05)。外周血淋巴细胞和癌组织的MRP1阴性组和阳性组二者复发或转移率均差异无统计学意义(P>0.05),癌旁组织的MRP1阴性组和阳性组间复发或转移率差异有统计学意义(P<0.05)。外周血淋巴细胞、肝癌组织及癌旁组织MRP1阴性表达组的中位生存期均明显长于MRP1阳性表达组、生存率均明显高于阳性组。结论检测癌旁组织MRP1对于评估肿瘤转移复发具有重要临床意义;外周血淋巴细胞、肝癌组织及癌旁组织MRP1表达的检测可以用于评估肝癌术后生存期、生存率;外周血淋巴细胞MRP1表达的检测具有推广应用价值。; Objective To investigate the value of predicting metastases or relapse and life-span of patients who are first diagnosed primary liver carcinoma and surgery as main therapy methodby chemotherapy detecting the expression of MRP1(multidrug resistance-associated protein)of PBL(peripheral blood lymphocyte) and cancerous tissues and para-carcinoma tissues.Methods Detect the expression of MRP1 of PBL and cancerous tissues and para-carcinoma tissues of 26 patients by flow cytometry,and then correspondent with patients after operation.Analysing the relation-ship between the expression of MRP1 and metastases or relapse or life-span,the contrast which is better when predicting metastases or relapse and life-span.Result 1.In those patients who are first diagnosed primary liver carcinoma the rates of expression of MRP1 in cancerous tissues and PBL and para-carcinoma tissues are 61.5%、53.8%and50.0%.But they have no great difference(P>0.05);2.the rate of relapse of MRP1-and MRP1+ in PBL and cancerous tissues have no great difference(P>0.05);that in para-carcinoma tissues have great difference(P<0.05);3.the median survival period of the patients with negative MRP1 expression is remarkably longer than that of patients with postive MRP1 expression,the rate of survival is higher than that of patients with postive MRP1 expression.Conclusion Detecting the expression of MRP1 of para-carcinoma tissues has more significant in predicting the metastases or relapse;Detecting the expression of MRP1 of PBL and cancerous tissues and para-carcinoma tissues can predict survival period and the rate of survival after patient’s surgery;Detecting the expression of MRP1 of PBL has good value of popularization.; 【作者单位】厦门大学附属中山医院临床检验中心；厦门大学附属中山医院临床检验中心；集美大学生物工程院；【作者英文名】CHAO Peng-li,ZHANG Zhong-ying,LIU Li-li,et al.(Center of Clinical Laboratory,Affiliated Zhongshan Hospital of Xiamen University,Xiamen 361004,China)
语种	中文
内容类型	期刊论文
源URL	[http://ir.calis.edu.cn/hdl/235041/18635]
专题	集美大学
推荐引用方式 GB/T 7714	晁鹏丽,张忠英,刘莉莉,等. 肝癌组织、外周血淋巴细胞和癌旁组织MRP1的表达对评估原发性肝癌预后的价值比较[J]. http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=lcwk200807011&dbcode=CJFQ&dbname=CJFQ2008,2012, 2012.
APA	晁鹏丽,张忠英,刘莉莉,&陈俊.(2012).肝癌组织、外周血淋巴细胞和癌旁组织MRP1的表达对评估原发性肝癌预后的价值比较.http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=lcwk200807011&dbcode=CJFQ&dbname=CJFQ2008.
MLA	晁鹏丽,et al."肝癌组织、外周血淋巴细胞和癌旁组织MRP1的表达对评估原发性肝癌预后的价值比较".http://epub.edu.cnki.net/grid2008/brief/detailj.aspx?filename=lcwk200807011&dbcode=CJFQ&dbname=CJFQ2008 (2012).