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	Atg5 regulates late endosome and lysosome biogenesis
	PENG JunYa ; ZHANG Ran ; CUI YiTong ; LIU HaoDong ; ZHAO XiaoXin ; HUANG Lei ; HU MingXu ; YUAN XiaoXi ; MA BenYu ; MA XiaoWei ; TAKASHI Ueno ; MASAAKI Komatsu ; LIANG XingJie ; YU Li ; PENG JunYa ; ZHANG Ran ; CUI YiTong ; LIU HaoDong ; ZHAO XiaoXin ; HUANG Lei ; HU MingXu ; YUAN XiaoXi ; MA BenYu ; MA XiaoWei ; TAKASHI Ueno ; MASAAKI Komatsu ; LIANG XingJie ; YU Li
	2016-03-30 ; 2016-03-30
关键词	endosome/lysosome biogenesis atg5 autophagy Q26
其他题名	Atg5 regulates late endosome and lysosome biogenesis
中文摘要	Autophagy is an evolutionarily conserved lysosome-based degradation process.Atg5 plays a very important role in autophagosome formation.Here we show that Atg5 is required for biogenesis of late endosomes and lysosomes in an autophagy-independent manner.In Atg5 cells,but not in other essential autophagy genes defecting cells,recycling and retrieval of late endosomal components from hybrid organelles are impaired,causing persistent hybrid organelles and defective formation of late endosomes and lysosomes.Defective retrieval of late endosomal components from hybrid organelles resulting from impaired recruitment of a component of V1-ATPase to acidic organelles blocks the pH-dependent retrieval of late endosomal components from hybrid organelles.Lowering the intracellular pH restores late endosome/lysosome biogenesis in Atg5 cells.Our data demonstrate an unexpected role of Atg5 and shed new light on late endosome and lysosome biogenesis.; Autophagy is an evolutionarily conserved lysosome-based degradation process. Atg5 plays a very important role in autopha- gosome formation. Here we show that Atg5 is required for biogenesis of late endosomes and lysosomes in an autopha- gy-independent manner. In Atg5 cells, but not in other essential autophagy genes defecting cells, recycling and retrieval of late endosomal components from hybrid organelles are impaired, causing persistent hybrid organelles and defective formation of late endosomes and lysosomes. Defective retrieval of late endosomal components from hybrid organelles resulting from impaired recruitment of a component of V1-ATPase to acidic organelles blocks the pH-dependent retrieval of late endosomal components from hybrid organelles. Lowering the intracellular pH restores late endosome/lysosome biogenesis in Atg5 cells. Our data demonstrate an unexpected role of Atg5 and shed new light on late endosome and lysosome biogenesis.
语种	英语 ; 英语
内容类型	期刊论文
源URL	[http://ir.lib.tsinghua.edu.cn/ir/item.do?handle=123456789/148419]
专题	清华大学
推荐引用方式 GB/T 7714	PENG JunYa,ZHANG Ran,CUI YiTong,et al. Atg5 regulates late endosome and lysosome biogenesis[J],2016, 2016.
APA	PENG JunYa.,ZHANG Ran.,CUI YiTong.,LIU HaoDong.,ZHAO XiaoXin.,...&YU Li.(2016).Atg5 regulates late endosome and lysosome biogenesis..
MLA	PENG JunYa,et al."Atg5 regulates late endosome and lysosome biogenesis".(2016).

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