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	The mitochondrial function was impaired in APP knockout mouse embryo fibroblast cells
	Sheng BaiYang ; Niu Ying ; Zhou Hui ; Yan JiaXin ; Zhao NanMing ; Zhang XiuFang ; Gong YanDao
	2010-10-12 ; 2010-10-12
关键词	amyloid precursor protein (APP) Alzheimer's disease mitochondria mitochondrial membrane potential Cytochrome c oxidase activity AMYLOID-PRECURSOR PROTEIN NEURAL STEM-CELLS ALZHEIMERS-DISEASE PROLIFERATION BRAIN MICE KERATINOCYTES Multidisciplinary Sciences
中文摘要	The amyloid precursor protein (APP) is recognized as the source of A beta, which plays an important role in Alzheimer's disease. However, the biological function of APP is obscure. Previous studies showed that mitochondria could be a target of APP. In this work, APP knockout mouse embryo fibroblast (MEF) cells were used to test if APP plays any role in maintaining the mitochondrial function. As the result, APP knockout MEF cells (APP(-/-) cells) showed the abnormal mitochondrial function, including slower cell proliferation, lower mitochondrial membrane potential, lower intracellular ROS, higher mitochondrial membrane fluidity and lower cytochrome c oxidase activity than their wild-type counterparts. However, no change was found in the amount of mitochondria in MEF APP(-/-) cells.
语种	英语 ; 英语
出版者	SCIENCE PRESS ; BEIJING ; 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81867]
专题	清华大学
推荐引用方式 GB/T 7714	Sheng BaiYang,Niu Ying,Zhou Hui,et al. The mitochondrial function was impaired in APP knockout mouse embryo fibroblast cells[J],2010, 2010.
APA	Sheng BaiYang.,Niu Ying.,Zhou Hui.,Yan JiaXin.,Zhao NanMing.,...&Gong YanDao.(2010).The mitochondrial function was impaired in APP knockout mouse embryo fibroblast cells..
MLA	Sheng BaiYang,et al."The mitochondrial function was impaired in APP knockout mouse embryo fibroblast cells".(2010).

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