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	Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells
	Geng, X. ; Zhou, Q. H. ; Kage-Nakadai, E. ; Shi, Y. ; Yan, N. ; Mitani, S. ; Xue, D.
	2010-10-12 ; 2010-10-12 ; OCT
关键词	germ cell death Caenorhabditis elegans CED-3 caspase activation cell death inhibitor DEATH ACTIVATION PROTEIN IDENTIFICATION MECHANISMS NEMATODE IAP Biochemistry & Molecular Biology Cell Biology
中文摘要	In Caenorhabditis elegans, apoptosis in germ cells is mediated by the same core apoptotic machinery that controls apoptosis in somatic cells. These include the CED-3 caspase, the CED-3 activator CED-4, and the cell death inhibitor CED-9. However, germline apoptosis also differs from somatic apoptosis in its regulation. We found that CSP-3, a caspase homolog that blocks CED-3 autoactivation and apoptosis in somatic cells, does not affect apoptosis in germ cells. Interestingly, the second C. elegans caspase homolog, CSP-2, shares sequence similarity to both catalytic subunits of the CED-3 caspase, and surprisingly, contains a stretch of sequence that is almost identical to that of CSP-3. Unlike CSP-3 that acts specifically in somatic cells, loss of CSP-2 causes increased apoptosis only in germ cells, suggesting that CSP-2 is a germ cell-specific apoptosis inhibitor. Moreover, like CSP-3, CSP-2 associates with the CED-3 zymogen and inhibits its autoactivation, but does not inhibit CED-4-induced CED- 3 activation or the activity of the activated CED-3 protease. Thus, two different C. elegans caspase homologs use the same mechanism to prevent caspase autoactivation and apoptosis in different tissues, suggesting that this could be a generally applicable strategy for regulating caspase activation and apoptosis.
语种	英语 ; 英语
出版者	NATURE PUBLISHING GROUP ; LONDON ; MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81814]
专题	清华大学
推荐引用方式 GB/T 7714	Geng, X.,Zhou, Q. H.,Kage-Nakadai, E.,et al. Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells[J],2010, 2010, OCT.
APA	Geng, X..,Zhou, Q. H..,Kage-Nakadai, E..,Shi, Y..,Yan, N..,...&Xue, D..(2010).Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells..
MLA	Geng, X.,et al."Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells".(2010).

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