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	Abnormal cleavage of APP impairs its functions in cell adhesion and migration
	Sheng, Baiyang ; Song, Bo ; Zheng, Zhenhuan ; Zhou, Fangfang ; Lu, Guangyuan ; Zhao, Nanming ; Zhang, Xiufang ; Gong, Yandao
	2010-10-12 ; 2010-10-12
关键词	Amyloid precursor protein (APP) Cell adhesion Cell migration Alzheimer's disease AMYLOID PRECURSOR PROTEIN ALZHEIMERS-DISEASE DECREASES ADHESION GROWTH-FACTOR PROLIFERATION KERATINOCYTES PRESENILIN-1 TRAFFICKING EXPRESSION MEMBRANE Neurosciences
中文摘要	Amyloid precursor protein (APP) is expressed ubiquitously but its wrong cleavage Only Occurs in central nervous system. In this research, overexpression of wild type human APP695 was found to Stimulate the adhesion and migration of N2a cells. In the cells co-transfected by familial Alzheimer's disease (FAD)linked Swedish mutant of APP695 gene Plus Delta E9 deleted presenilin1 gene (N2a/Swe.Delta 9), however, this stimulating function was impaired compared to that in the cells co-transfected by Swedish mutant of APP695 gene plus dominant negative mutant of presenilin1 D385A gene (N2a/Swe.385). Furthermore, it was also found that the phosphorylation of FAK Tyr-861 and GSK-3 beta Ser-9 was reduced in N2a/Swe.Delta 9 cells, which call be possibly taken as a reasonable explanation for the underlying mechanism. Our results Suggest that impaired cell adhesion and migration induced by abnormal cleavage of APP could contribute to the pathological effects in FAD brain. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER IRELAND LTD ; CLARE ; ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81813]
专题	清华大学
推荐引用方式 GB/T 7714	Sheng, Baiyang,Song, Bo,Zheng, Zhenhuan,et al. Abnormal cleavage of APP impairs its functions in cell adhesion and migration[J],2010, 2010.
APA	Sheng, Baiyang.,Song, Bo.,Zheng, Zhenhuan.,Zhou, Fangfang.,Lu, Guangyuan.,...&Gong, Yandao.(2010).Abnormal cleavage of APP impairs its functions in cell adhesion and migration..
MLA	Sheng, Baiyang,et al."Abnormal cleavage of APP impairs its functions in cell adhesion and migration".(2010).

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