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	Nuclear protein I kappa B-zeta inhibits the activity of STAT3
	Wu, Zhihao ; Zhang, Xiaoai ; Yang, Juntao ; Wu, Guangzhou ; Zhang, Ying ; Yuan, Yanzhi ; Jin, Chaozhi ; Chang, Zhijie ; Wang, Jian ; Yang, Xiaoming ; He, Fuchu
	2010-10-12 ; 2010-10-12
关键词	I kappa B-zeta STAT3 Inhibition Transcription Apoptosis SIGNAL TRANSDUCERS JAK/STAT PATHWAY JAK-STAT ACTIVATION CANCER GENE EXPRESSION SURVIVAL RECEPTOR FAMILY Biochemistry & Molecular Biology Biophysics
中文摘要	STAT3 (Signal transducer and activator of transcription 3) is a key transcription factor of the JAK-STAT (Janus kinase/signal transducer and activator of transcription) pathway that regulates cell proliferation and apoptosis. Activation of STAT3 is under tight regulation, and yet the different signaling pathways and the mechanisms that regulate its activity remain to be elucidated. Using a yeast two-hybrid screening, we have identified a nuclear protein I kappa B-zeta that interacts in a novel way with STAT3. This physical interaction was further confirmed by co-immunoprecipitation assays. The interaction regions were mapped to the coiled-coil domain of STAT3 and the C-terminal of I kappa B-zeta Overexpression Of I kappa B-zeta inhibited the transcriptional activity of STAT3. It also suppressed cell growth and induced cell apoptosis in SRC-simulated cells, which is partially mediated by down-regulation of expression of a known STAT3 target gene, MCL1. Our results suggest that I kappa B-zeta is a negative regulator of STAT3, and demonstrate a novel mechanism in which a component of the NF-kappa B signaling pathway inhibits the activation of STAT3. (C) 2009 Elsevier Inc. All rights reserved.
语种	英语 ; 英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE ; SAN DIEGO ; 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81809]
专题	清华大学
推荐引用方式 GB/T 7714	Wu, Zhihao,Zhang, Xiaoai,Yang, Juntao,et al. Nuclear protein I kappa B-zeta inhibits the activity of STAT3[J],2010, 2010.
APA	Wu, Zhihao.,Zhang, Xiaoai.,Yang, Juntao.,Wu, Guangzhou.,Zhang, Ying.,...&He, Fuchu.(2010).Nuclear protein I kappa B-zeta inhibits the activity of STAT3..
MLA	Wu, Zhihao,et al."Nuclear protein I kappa B-zeta inhibits the activity of STAT3".(2010).

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