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	Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B
	Ye, Jing ; Li, John Zhong ; Liu, Yang ; Li, Xuanhe ; Yang, Tianshu ; Ma, Xiaodong ; Li, Qing ; Yao, Zemin ; Li, Peng
	2010-10-12 ; 2010-10-12
关键词	LOW-DENSITY LIPOPROTEIN TRIGLYCERIDE TRANSFER PROTEIN DIET-INDUCED OBESITY ENDOPLASMIC-RETICULUM PROTEASOMAL DEGRADATION INSULIN SENSITIVITY GOLGI-APPARATUS MOUSE-LIVER MICE SECRETION Cell Biology Endocrinology & Metabolism
中文摘要	Secretion of triacylglycerol-enriched very-low-density lipoproteins (VLDLs) from the liver is vital for maintaining plasma lipid homeostasis. However, the process of VLDL assembly and lipidation is not well characterized. Here, we observed that liver of Cideb null mice had higher levels of triacylglycerols accompanied by low level of VLDL secretion. Furthermore, VLDL particles secreted from hepatocytes of Cideb null mice have low levels of triacylglycerols but normal levels of apoB. We also observed that Cideb is localized to endoplasmic reticulum and lipid droplets. Importantly, we have identified apoB as a Cideb-inter-acting protein. By infecting adenoviruses expressing various Cideb truncations into hepatocytes of Cideb null mice, we found that Cideb requires both its apoB-binding and lipid droplet association domains to restore the secretion of triacyl glycerol-enriched VLDL particles. Our data suggest that Cideb promotes the formation of triacylglycerol-enriched VLDL particles and provides a molecular insight into VLDL lipidation and maturation in hepatocytes.
语种	英语 ; 英语
出版者	CELL PRESS ; CAMBRIDGE ; 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81787]
专题	清华大学
推荐引用方式 GB/T 7714	Ye, Jing,Li, John Zhong,Liu, Yang,et al. Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B[J],2010, 2010.
APA	Ye, Jing.,Li, John Zhong.,Liu, Yang.,Li, Xuanhe.,Yang, Tianshu.,...&Li, Peng.(2010).Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B..
MLA	Ye, Jing,et al."Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B".(2010).

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