Fibrinogen facilitates the anti-tumor effect of nonnative endostatin | |
Tang, Huadong ; Fu, Yan ; Lei, Qingxin ; Han, Qing ; Ploplis, Victoria A. ; Castellino, Francis J. ; Li, Ling ; Luo, Yongzhang | |
2010-10-12 ; 2010-10-12 | |
关键词 | Endostatin Fibrinogen Nonnative Anti-tumor Aggregation DISULFIDE BONDS TUMOR-GROWTH MODEL THERAPY PLASMA MICE ANGIOGENESIS FIBRONECTIN DEFICIENCY Biochemistry & Molecular Biology Biophysics |
中文摘要 | Endostatin is a potent inhibitor of tumor angiogenesis. Interestingly, normative endostatin also exhibits an anti-tumor effect, which remains a mystery so far. Here, we show that intravenous injection of nonnative endostatin results in tumor inhibition effect. Soluble and active endostatin is isolated from human blood after the addition of normative endostatin in vitro. By fractionation of the whole blood, we surprisingly identify fibrinogen specifically binding to and inhibiting the aggregation of normative endostatin. Moreover, the anti-tumor activity of normative endostatin is substantially impaired in fibrinogen-deficient mice. Our studies demonstrate that fibrinogen facilitates the anti-tumor effect of normative endostatin, which also provides new insights into the novel physiological function of fibrinogen. (c) 2009 Elsevier Inc. All rights reserved. |
语种 | 英语 ; 英语 |
出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE ; SAN DIEGO ; 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA |
内容类型 | 期刊论文 |
源URL | [http://hdl.handle.net/123456789/81777] ![]() |
专题 | 清华大学 |
推荐引用方式 GB/T 7714 | Tang, Huadong,Fu, Yan,Lei, Qingxin,et al. Fibrinogen facilitates the anti-tumor effect of nonnative endostatin[J],2010, 2010. |
APA | Tang, Huadong.,Fu, Yan.,Lei, Qingxin.,Han, Qing.,Ploplis, Victoria A..,...&Luo, Yongzhang.(2010).Fibrinogen facilitates the anti-tumor effect of nonnative endostatin.. |
MLA | Tang, Huadong,et al."Fibrinogen facilitates the anti-tumor effect of nonnative endostatin".(2010). |
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