QQ客服 官方微博 反馈留言

	Fibrinogen facilitates the anti-tumor effect of nonnative endostatin
	Tang, Huadong ; Fu, Yan ; Lei, Qingxin ; Han, Qing ; Ploplis, Victoria A. ; Castellino, Francis J. ; Li, Ling ; Luo, Yongzhang
	2010-10-12 ; 2010-10-12
关键词	Endostatin Fibrinogen Nonnative Anti-tumor Aggregation DISULFIDE BONDS TUMOR-GROWTH MODEL THERAPY PLASMA MICE ANGIOGENESIS FIBRONECTIN DEFICIENCY Biochemistry & Molecular Biology Biophysics
中文摘要	Endostatin is a potent inhibitor of tumor angiogenesis. Interestingly, normative endostatin also exhibits an anti-tumor effect, which remains a mystery so far. Here, we show that intravenous injection of nonnative endostatin results in tumor inhibition effect. Soluble and active endostatin is isolated from human blood after the addition of normative endostatin in vitro. By fractionation of the whole blood, we surprisingly identify fibrinogen specifically binding to and inhibiting the aggregation of normative endostatin. Moreover, the anti-tumor activity of normative endostatin is substantially impaired in fibrinogen-deficient mice. Our studies demonstrate that fibrinogen facilitates the anti-tumor effect of normative endostatin, which also provides new insights into the novel physiological function of fibrinogen. (c) 2009 Elsevier Inc. All rights reserved.
语种	英语 ; 英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE ; SAN DIEGO ; 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81777]
专题	清华大学
推荐引用方式 GB/T 7714	Tang, Huadong,Fu, Yan,Lei, Qingxin,et al. Fibrinogen facilitates the anti-tumor effect of nonnative endostatin[J],2010, 2010.
APA	Tang, Huadong.,Fu, Yan.,Lei, Qingxin.,Han, Qing.,Ploplis, Victoria A..,...&Luo, Yongzhang.(2010).Fibrinogen facilitates the anti-tumor effect of nonnative endostatin..
MLA	Tang, Huadong,et al."Fibrinogen facilitates the anti-tumor effect of nonnative endostatin".(2010).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。