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	An optical coherence tomography (OCT)-based air jet indentation system for measuring the mechanical properties of soft tissues
	Huang, Yan-Ping ; Zheng, Yong-Ping ; Wang, Shu-Zhe ; Chen, Zhong-Ping ; Huang, Qing-Hua ; He, Yong-Hong
	2010-10-12 ; 2010-10-12
关键词	indentation ultrasound indentation soft tissue elasticity air jet optical coherence tomography IN-VIVO ARTICULAR-CARTILAGE ULTRASOUND INDENTATION BIOMECHANICAL PROPERTIES BIPHASIC INDENTATION FINITE-ELEMENT ELASTOGRAPHY ELASTICITY DEFORMATION MODULUS Engineering, Multidisciplinary Instruments & Instrumentation
中文摘要	A novel noncontact indentation system with the combination of an air jet and optical coherence tomography (OCT) was presented in this paper for the quantitative measurement of the mechanical properties of soft tissues. The key idea of this method is to use a pressure-controlled air jet as an indenter to compress the soft tissue in a noncontact way and utilize the OCT signals to extract the deformation induced. This indentation system provides measurement and mapping of tissue elasticity for small specimens with high scanning speed. Experiments were performed on 27 silicone tissue-mimicking phantoms with different Young's moduli, which were also measured by uniaxial compression tests. The regression coefficient of the indentation force to the indentation depth (N mm(-1)) was used as an indicator of the stiffness of tissue under air jet indentation. Results showed that the stiffness coefficients measured by the current system correlated well with the corresponding Young's moduli obtained by conventional mechanical testing (r = 0.89, p < 0.001). Preliminary in vivo tests also showed that the change of soft tissue stiffness with and without the contraction of the underlying muscles in the hand could be differentiated by the current measurement. This system may have broad applications in tissue assessment and characterization where alterations of mechanical properties are involved, in particular with the potential of noncontact micro-indentation for tissues.
语种	英语 ; 英语
出版者	IOP PUBLISHING LTD ; BRISTOL ; DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81702]
专题	清华大学
推荐引用方式 GB/T 7714	Huang, Yan-Ping,Zheng, Yong-Ping,Wang, Shu-Zhe,et al. An optical coherence tomography (OCT)-based air jet indentation system for measuring the mechanical properties of soft tissues[J],2010, 2010.
APA	Huang, Yan-Ping,Zheng, Yong-Ping,Wang, Shu-Zhe,Chen, Zhong-Ping,Huang, Qing-Hua,&He, Yong-Hong.(2010).An optical coherence tomography (OCT)-based air jet indentation system for measuring the mechanical properties of soft tissues..
MLA	Huang, Yan-Ping,et al."An optical coherence tomography (OCT)-based air jet indentation system for measuring the mechanical properties of soft tissues".(2010).

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