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	A quantification model for apoptosis in mouse embryos in the early stage of fetation
	Wang PengFei ; Fu JianHua ; Ma WanYun ; Chen DieYan ; Lue DanYu ; Bai WenJia
	2010-10-12 ; 2010-10-12 ; OCT
关键词	apoptosis preimplantation mouse embryo TPLSM quantification model CELL-DEATH PREIMPLANTATION EMBRYOS BLASTOCYST EXPRESSION SURVIVAL Biology
中文摘要	Apoptosis is the most important inducement and modulator for embryos in the early stage of fetation, i.e. after the 8-cell stage, mostly the morula and blastula stage, to proceed to the stage of nonlinear development. Using a two-photon laser scanning microscopy (TPLSM) system, we obtained 3-dimensional (M) fluorescent images of preimplantation mouse embryos. A model for quantification was established. The statistical results for the spatial location of apoptosis bodies in embryos was obtained following image processing, as well as investigation of the kinetics of apoptosis. It was found that most (70%) apoptosis occurred in the trophectoderm, and the departure between the centroid and geometric center of embryos had a step transition when embryos developed into the 32-cell stage, which was consistent with the theoretical prediction that the blastocele would induce a symmetry break of the distribution of cells in embryos.
语种	英语 ; 英语
出版者	SCIENCE PRESS ; BEIJING ; 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81603]
专题	清华大学
推荐引用方式 GB/T 7714	Wang PengFei,Fu JianHua,Ma WanYun,et al. A quantification model for apoptosis in mouse embryos in the early stage of fetation[J],2010, 2010, OCT.
APA	Wang PengFei,Fu JianHua,Ma WanYun,Chen DieYan,Lue DanYu,&Bai WenJia.(2010).A quantification model for apoptosis in mouse embryos in the early stage of fetation..
MLA	Wang PengFei,et al."A quantification model for apoptosis in mouse embryos in the early stage of fetation".(2010).

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