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	Correlations of six related purine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients
	Xia, Jian-Fei ; Liang, Qiong-Lin ; Hu, Ping ; Wang, Yi-Ming ; Li, Ping ; Luo, Guo-An
	2010-10-12 ; 2010-10-12
关键词	Type 2 diabetes Diabetic nephropathy Biomarker Uric acid Xanthine Adenosine Inosine SERUM URIC-ACID NITRIC-OXIDE PRODUCTION ADENOSINE-DEAMINASE XANTHINE-OXIDASE PRECIS DATABASE GLUCOSE CONTROL RENAL-DISEASE MORTALITY ASSOCIATION DYSFUNCTION Medical Laboratory Technology
中文摘要	Objectives: The assessment of the clinical significance of adenosine, adenine, inosine, xanthine, hypoxanthine and uric acid concentrations in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) for the detection of the relationship between purine metabolites and disease. Design and methods: The study group consisted of 119 subjects which were divided into three groups: control (n=31), type 2 diabetes without nephropathy (DM, n=23) and with nephropathy (DN, n=65). Levels of related metabolites were measured in plasma of all participants. Results: There is a significant increase of levels of adenosine (P<0.001), inosine (P<0.001), xanthine (P=0.012) and uric acid (P=0.016) with DN compared to DM. The level of xanthine oxidase (reflected by the uric acid: xanthine) did not change. Conclusion: The levels of adenosine, inosine, uric acid and xanthine may be useful for monitoring the progression of DM and evaluating the treatment.,c, 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
语种	英语 ; 英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD ; OXFORD ; THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81047]
专题	清华大学
推荐引用方式 GB/T 7714	Xia, Jian-Fei,Liang, Qiong-Lin,Hu, Ping,et al. Correlations of six related purine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients[J],2010, 2010.
APA	Xia, Jian-Fei,Liang, Qiong-Lin,Hu, Ping,Wang, Yi-Ming,Li, Ping,&Luo, Guo-An.(2010).Correlations of six related purine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients..
MLA	Xia, Jian-Fei,et al."Correlations of six related purine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients".(2010).

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