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	Synthesis, characterization, and controllable drug release of pH-sensitive hybrid magnetic nanoparticles
	Zhou, Lilin ; Yuan, Jinying ; Yuan, Weizhong ; Sui, Xiaofeng ; Wu, Sizhu ; Li, Zhaolong ; Shen, Dezhong
	2010-10-12 ; 2010-10-12
关键词	Targeted drug delivery PH-responsive Hybrid nanoparticle Magnetite Atom transfer radical polymerization TRANSFER RADICAL POLYMERIZATION RING-OPENING POLYMERIZATION 2-(DIMETHYLAMINO)ETHYL METHACRYLATE COMPOSITE NANOPARTICLES BIOMEDICAL APPLICATIONS METHYL-METHACRYLATE BLOCK-COPOLYMER MICROSPHERES POLY(EPSILON-CAPROLACTONE) ATRP Materials Science, Multidisciplinary Physics, Condensed Matter
中文摘要	The synthesis of magnetite nanoparticles coated with pH-sensitive poly((2-dimethylamino) ethyl methacrylate)(PDMAEMA) via atom transfer radical polymerization(ATRP) for use as novel potential carriers for targeted drug delivery and controllable release is reported. The organic/inorganic hybrid nanoparticles were obtained with an arrow molecular weight distribution. The pH-sensitivity of the nanoparticles was investigated by the measurement of the pH dependence of hydrodynamic radius and the superparamagnetism was illustrated by vibrating sample magnetometer(VSM). The behavior of model drug phenolphthalein released from the nanoparticles indicated that the rate of drug release could be effectively controlled by altering the pH values of the environment. (C) 2009 Elsevier B. V. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER SCIENCE BV ; AMSTERDAM ; PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81038]
专题	清华大学
推荐引用方式 GB/T 7714	Zhou, Lilin,Yuan, Jinying,Yuan, Weizhong,et al. Synthesis, characterization, and controllable drug release of pH-sensitive hybrid magnetic nanoparticles[J],2010, 2010.
APA	Zhou, Lilin.,Yuan, Jinying.,Yuan, Weizhong.,Sui, Xiaofeng.,Wu, Sizhu.,...&Shen, Dezhong.(2010).Synthesis, characterization, and controllable drug release of pH-sensitive hybrid magnetic nanoparticles..
MLA	Zhou, Lilin,et al."Synthesis, characterization, and controllable drug release of pH-sensitive hybrid magnetic nanoparticles".(2010).

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