| Synthesis and Cytotoxicity Screening of Piperazine-1-carbodithioate Derivatives of 2-Substituted Quinazolin-4(3H)-ones | |
| Cao, Sheng-Li ; Guo, Yan-Wen ; Wang, Xian-Bo ; Zhang, Mei ; Feng, Yu-Ping ; Jiang, Yu-Yang ; Wang, Yue ; Gao, Qian ; Ren, Jian | |
| 2010-10-12 ; 2010-10-12 | |
| 关键词 | Dithiocarbamate Cytotoxicity Quinazolin-4(3H)-one Screening Synthesis THYMIDYLATE SYNTHASE INHIBITORS HETEROCYCLYLMETHYLAMINO-CARBODITHIOATE DERIVATIVES VITRO ANTITUMOR-ACTIVITY CRUCIFEROUS PHYTOALEXINS C2 POSITION 4-(3H)-QUINAZOLINONE SUBSTITUENTS CANCER CHAINS AGENTS Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy |
| 中文摘要 | A new series of piperazine-1-carbodithioate derivatives of 2-substituted quinazolin-4(3H)-ones were synthesized via a five-steps procedure starting from 2-amino-5-methylbenzoic acid. The cytotoxicity of the resulting compounds against A-549 (human lung cancer), HCT-8 (human colon cancer), HepG2 (human liver cancer), and K562 (human myelogenous leukaemia) cell lines was determined by the MTT assay. Preliminary screening results of these compounds are reported. |
| 语种 | 英语 ; 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH ; WEINHEIM ; PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/80948]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Cao, Sheng-Li,Guo, Yan-Wen,Wang, Xian-Bo,et al. Synthesis and Cytotoxicity Screening of Piperazine-1-carbodithioate Derivatives of 2-Substituted Quinazolin-4(3H)-ones[J],2010, 2010. |
| APA | Cao, Sheng-Li.,Guo, Yan-Wen.,Wang, Xian-Bo.,Zhang, Mei.,Feng, Yu-Ping.,...&Ren, Jian.(2010).Synthesis and Cytotoxicity Screening of Piperazine-1-carbodithioate Derivatives of 2-Substituted Quinazolin-4(3H)-ones.. |
| MLA | Cao, Sheng-Li,et al."Synthesis and Cytotoxicity Screening of Piperazine-1-carbodithioate Derivatives of 2-Substituted Quinazolin-4(3H)-ones".(2010). |
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