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	A domino three-component condensation of ortho-haloacetophenones with urea or amines: a novel one-pot synthesis of halogen-substituted quinolines
	Qi, Chuanmei ; Zheng, Qingwei ; Hua, Ruimao
	2010-10-12 ; 2010-10-12
关键词	Amine Condensation o-Haloacetophenone Quinoline Urea ACRIDONE ALKALOIDS HETEROCYCLIC-COMPOUNDS DERIVATIVES QUINAZOLINE CHEMISTRY DISCOVERY ALDEHYDES PYRIDINE DRUG Chemistry, Organic
中文摘要	Halogen-substituted quinolines have been synthesized in good yields by the condensation and cyclization of two molecules of ortho-haloacetophenones with urea or primary amines. The formation of halogen-substituted quinolines takes place through the unexpected catalyst-free cleavage of C(sp(2))-X (X=Cl, Br), alpha-C(sp(3))-H bonds and formation of C-C, C-N bonds in a selective manner. The attractive features of the present synthetic method for halogen-substituted quinolines include catalyst-free, one-pot process, easy availability of starting materials, and introduction of halogen on the quinoline ring for further transformation. (C) 2008 Elsevier Ltd. All rights reserved.
语种	英语 ; 英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD ; OXFORD ; THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/80883]
专题	清华大学
推荐引用方式 GB/T 7714	Qi, Chuanmei,Zheng, Qingwei,Hua, Ruimao. A domino three-component condensation of ortho-haloacetophenones with urea or amines: a novel one-pot synthesis of halogen-substituted quinolines[J],2010, 2010.
APA	Qi, Chuanmei,Zheng, Qingwei,&Hua, Ruimao.(2010).A domino three-component condensation of ortho-haloacetophenones with urea or amines: a novel one-pot synthesis of halogen-substituted quinolines..
MLA	Qi, Chuanmei,et al."A domino three-component condensation of ortho-haloacetophenones with urea or amines: a novel one-pot synthesis of halogen-substituted quinolines".(2010).

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