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	A carbon nanotubes assisted strategy for insulin detection and insulin proteolysis assay
	Wang, Ying ; Li, Jinghong
	2010-10-12 ; 2010-10-12
关键词	Insulin Carbon nanotubes Electrocatalysis Proteolysis PHYSIOLOGICAL PH AMPEROMETRIC DETECTION C-PEPTIDE ELECTRODES FUNCTIONALIZATION OXIDATION IMMOBILIZATION NANOPARTICLES IMMUNOASSAY COMPOSITE Chemistry, Analytical
中文摘要	The carbon nanotubes (CNTs) assisted strategy has been proposed for insulin sensing and insulin proteolysis analysis. Experiments demonstrated that this strategy could be used for trace insulin determination with a low detection limit 7.75 ng mL(-1) (S/N = 3) and a detection range from 20 ng mL-1 to 400 ng mL-1. Both biocompatibility and intrinsic conductivity of pristine CNTs enabled them to act an excellent biosensing platform for the realization of direct electrochemistry and electrocatalysis of insulin. Compared with the present methods, the proposed strategy could realize the trace insulin detection without electrode modifications. It is more convenient and simpler than those based on the chemically modified electrodes. This method also made the CNTs as the indicator for insulin proteolysis analysis so that the biological process could be studied by electron microscope, electrochemical methods and digital camera. CNTs obtained after the proteolysis showed the same capabilities as the pristine ones in electrochemical signal enhancement and could participate in the bio-circle repeatedly. (C) 2009 Elsevier B.V. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER SCIENCE BV ; AMSTERDAM ; PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/80802]
专题	清华大学
推荐引用方式 GB/T 7714	Wang, Ying,Li, Jinghong. A carbon nanotubes assisted strategy for insulin detection and insulin proteolysis assay[J],2010, 2010.
APA	Wang, Ying,&Li, Jinghong.(2010).A carbon nanotubes assisted strategy for insulin detection and insulin proteolysis assay..
MLA	Wang, Ying,et al."A carbon nanotubes assisted strategy for insulin detection and insulin proteolysis assay".(2010).

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