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	A Miniature Probe for Ultrasonic Penetration of a Single Cell
	Wu, Ting ; Zhou, Zhaoying ; Wang, Qun ; Yang, Xing ; Xiao, Mingfei
	2010-10-12 ; 2010-10-12
关键词	Ultrasonic penetration FEM ultrasonic probe cell generator ATOMIC-FORCE MICROSCOPE ELECTROPORATION MEMBRANES Chemistry, Analytical Electrochemistry Instruments & Instrumentation
中文摘要	Although ultrasound cavitation must be avoided for safe diagnostic applications, the ability of ultrasound to disrupt cell membranes has taken on increasing significance as a method to facilitate drug and gene delivery. A new ultrasonic resonance driving method is introduced to penetrate rigid wall plant cells or oocytes with springy cell membranes. When a reasonable design is created, ultrasound can gather energy and increase the amplitude factor. Ultrasonic penetration enables exogenous materials to enter cells without damaging them by utilizing instant acceleration. This paper seeks to develop a miniature ultrasonic probe experiment system for cell penetration. A miniature ultrasonic probe is designed and optimized using the Precise Four Terminal Network Method and Finite Element Method (FEM) and an ultrasonic generator to drive the probe is designed. The system was able to successfully puncture a single fish cell.
语种	英语 ; 英语
出版者	MOLECULAR DIVERSITY PRESERVATION INT ; BASEL ; MATTHAEUSSTRASSE 11, CH-4057 BASEL, SWITZERLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/80366]
专题	清华大学
推荐引用方式 GB/T 7714	Wu, Ting,Zhou, Zhaoying,Wang, Qun,et al. A Miniature Probe for Ultrasonic Penetration of a Single Cell[J],2010, 2010.
APA	Wu, Ting,Zhou, Zhaoying,Wang, Qun,Yang, Xing,&Xiao, Mingfei.(2010).A Miniature Probe for Ultrasonic Penetration of a Single Cell..
MLA	Wu, Ting,et al."A Miniature Probe for Ultrasonic Penetration of a Single Cell".(2010).

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