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	Preparation of monodispersed chitosan microspheres and in situ encapsulation of BSA in a co-axial microfluidic device
	Xu, J. H. ; Li, S. W. ; Tostado, C. ; Lan, W. J. ; Luo, G. S.
	2010-10-12 ; 2010-10-12
关键词	Chitosan Microsphere Monodispersed Microfluidic device BSA DROPLET FORMATION DRUG-DELIVERY MICROPARTICLES SIZE FABRICATION HYDROGELS POLYMER CHIP Engineering, Biomedical Nanoscience & Nanotechnology
中文摘要	This work describes a novel microfluidic method to prepare monodispersed chitosan microspheres by using the solvent extraction method. Our strategy is that a chitosan/acetic acid aqueous solution is emulsified in an organic phase containing the extractant by using the co-flowing shear method in a co-axial microfluidic device. The formed droplets are in situ solidified within a synthesizing channel by the extraction of acetic acid from the chitosan aqueous droplets to the organic solution. Based on this approach, the size of chitosan microspheres can be successfully controlled from 100 mu m to 700 mu m in diameter with a variation of less than 4%. Furthermore, high loading efficiency (> 95%) of Bovine serum albumin (BSA) can be in situ encapsulated. The present method has the advantages of actively controlling the droplet diameter, narrow size distribution, good sphericity, and having a simple and low cost process, with a high throughput. This approach for the preparation of chitosan microspheres will provide many potential applications for pharmaceutical area.
语种	英语 ; 英语
出版者	SPRINGER ; DORDRECHT ; VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/79494]
专题	清华大学
推荐引用方式 GB/T 7714	Xu, J. H.,Li, S. W.,Tostado, C.,et al. Preparation of monodispersed chitosan microspheres and in situ encapsulation of BSA in a co-axial microfluidic device[J],2010, 2010.
APA	Xu, J. H.,Li, S. W.,Tostado, C.,Lan, W. J.,&Luo, G. S..(2010).Preparation of monodispersed chitosan microspheres and in situ encapsulation of BSA in a co-axial microfluidic device..
MLA	Xu, J. H.,et al."Preparation of monodispersed chitosan microspheres and in situ encapsulation of BSA in a co-axial microfluidic device".(2010).

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