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	The effect of pH on the polymer degradation and drug release from PLGA-mPEG microparticles
	Jin Li ; Guoqiang Jiang ; Fuxin Ding
	2010-10-12 ; 2010-10-12
关键词	Experimental/ biomedical materials crystallisation drugs Fourier transform spectra infrared spectra molecular weight nanobiotechnology nanoparticles pH polymers solubility surface morphology/ pH polymer degradation drug release PLGA-mPEG microparticles degradation mechanism poly (dl-lactide-co-glycolic acid)- methoxypoly (ethyleneglycol) methotrexate antirheumatic drug water uptake carboxylic groups chain scission polymer composition particle surface molecular weight surface degradation heterogeneous bulk degradation particle agglomeration acidic environment Fourier transform infrared spectrum crystallization transport paths drug solubility drug crystallinity/ A8770M Biomedical materials A6140K Structure of polymers, elastomers, and plastics A8160J Surface treatment and degradation of polymers and plastics A8770G Patient care and treatment A6146 Structure of solid clusters, nanoparticles, nanotubes and nanostructured materials A8116 Methods of nanofabrication and processing A6820 Solid surface structure A7830L Infrared and Raman spectra in disordered solids A6475 Solubility, segregation, and mixing
中文摘要	/i In/ /i vitro/ drug release and degradation mechanism of Poly (/i dl/-lactide-/i co/-glycolic acid)- methoxypoly (ethyleneglycol) (PLGA-mPEG) microparticles were investigated under different pH conditions. Methotrexate(MTX), an antirheumatic drug, was employed as the model drug. In polyester-based microparticle system, two main issues involved in degradation were water uptake and the carboxylic groups produced by chain scission. Polymer composition was identified to be responsible for the odd degradation behavior in different releasing media. Because of the exposure of mPEG chains at the particle surface, microparticle degradation showed apparent different mechanism under the investigated releasing conditions. At pH 10.08, microparticles exhibited rapid weight loss but slower molecular weight decrease, and the degradation pattern was close to surface degradation. At pH 7.4, microparticles underwent heterogeneous bulk degradation. However, at pH 1.2, it showed fastest molecular weight decrease while slowest weight loss, and homogeneous degradation was observed. Particle agglomeration was also seen in acidic environment. Fourier transform infrared (FTIR) spectrum results indicated the crystallization of drugs under the low pH condition. Drug release was dependent on transport paths and drug property. These two factors were highly controlled by the polymer degradation and drug solubility in the releasing media as well as drug crystallinity. c 2008 Wiley Periodicals, Inc.
语种	英语
出版者	John Wiley & Sons Inc. ; USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/79429]
专题	清华大学
推荐引用方式 GB/T 7714	Jin Li,Guoqiang Jiang,Fuxin Ding. The effect of pH on the polymer degradation and drug release from PLGA-mPEG microparticles[J],2010, 2010.
APA	Jin Li,Guoqiang Jiang,&Fuxin Ding.(2010).The effect of pH on the polymer degradation and drug release from PLGA-mPEG microparticles..
MLA	Jin Li,et al."The effect of pH on the polymer degradation and drug release from PLGA-mPEG microparticles".(2010).

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