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	高效液相色谱-电喷雾质谱(HPLC-ESI-MS/MS)测定新型抗癌铂配合物
	苏强 ; 刘清飞 ; 梁琼麟 ; 王义明 ; 毕开顺 ; 刘伟平 ; 罗国安 ; SU Qiang ; LIU Qing-Fei ; LIANG Qiong-Lin ; WANG Yi-Ming ; BI Kai-Shun ; LIU Wei-Ping ; LUO Guo-An
	2010-07-19 ; 2010-07-19
关键词	电喷雾质谱 铂配合物 抗癌药物 ESI-MS Platinum complex Antitumour drug R927
其他题名	Application of HPLC-ESI-MS/MS to the Determination of a Novel Antitumour Platinum Complex
中文摘要	A novel platinum complex,named as saliplatin,was designed,synthesized and characterized with element analysis,coupled inductively plasma-mass spectrum,gravitational thermal-differential thermal analysis,ultraviolet-visible absorption spectrum,infrared spectrum,fast atom bombment mass spectrum and 1H NMR,etc.Its purity was investigated and determined.HPLC-ESI-MS was employed to separate the platinum complex and the impurity,and to identify and quantify the latter.It proved that the impurity in this novel compound was 3,5-diisopropylsalycilic acid,a reactant used in the synthesis of the novel platinum complex,identified with ESI-MS.The mass fraction was determined with HPLC as 4.3%,which meant that the purity of this new substance was 95.7%.; 清华大学裕元医学研究基金(批准号:20240000529)资助
语种	中文 ; 中文
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/75361]
专题	清华大学
推荐引用方式 GB/T 7714	苏强,刘清飞,梁琼麟,等. 高效液相色谱-电喷雾质谱(HPLC-ESI-MS/MS)测定新型抗癌铂配合物[J],2010, 2010.
APA	苏强.,刘清飞.,梁琼麟.,王义明.,毕开顺.,...&LUO Guo-An.(2010).高效液相色谱-电喷雾质谱(HPLC-ESI-MS/MS)测定新型抗癌铂配合物..
MLA	苏强,et al."高效液相色谱-电喷雾质谱(HPLC-ESI-MS/MS)测定新型抗癌铂配合物".(2010).

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