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	改性壳聚糖树脂对利尿剂的吸附性能
	陈飞 ; 骆广生 ; 王玉军 ; CHEN Fei ; LUO Guangsheng ; WANG Yujun
	2010-06-10 ; 2010-06-10
关键词	改性壳聚糖 利尿剂 吸附 Chemical modified chitosan, Diuretics, Adsorption TQ460
其他题名	STUDIES ON ADSORPTION PROPERTIES OF CHEMICALLY MODIFIEDCHITOSAN RESINS TO DIURETICS
中文摘要	用琥珀酸酐、苯甲酸酐、聚乙烯亚胺和 3 氯 2 羟丙基三甲基氯化铵对壳聚糖进行改性 ,分别在其氨基上引入羧基、苯环、多氨基和季胺基 ,并利用红外谱图对于改性后的壳聚糖的结构进行了分析 .应用相转移法制备了 4种改性壳聚糖的微球 ,实验研究了这 4种微球对 9种不同利尿剂的吸附性能 .结果表明 ,由于Lewis酸碱相互作用 ,引入羧基后的壳聚糖树脂对 3种碱性利尿剂的吸附量有了 15 %～ 36 %的提高 ,而引入多氨基的壳聚糖树脂对四种酸性利尿剂的吸附量分别提高了 4 8 5 %～ 2 0 9% ;由于苯环和利尿剂的憎水性基团的相互作用 ,引入苯环后的壳聚糖树脂对所有的利尿剂的吸附量都有所提高 ,其幅度为 15 %～ 6 1% ;因为季胺基团和羧基之间发生的离子交换作用 ,引入季胺基后的树脂对具有羧基的利尿剂吸附量有显著的提高 ,尤其对布美它尼的吸附量提高了 2倍以上 .; Four types of chitosan beads,carboxylic chitosan (SUC-CS),benzoyl chitosan (BEN-CS),polyethyleneiminated chitosan (PEI-CS) and quaternaminated chitosan (QA-CS) were prepared using the wet phase-inversion method and chemical modification with the chemicals of succinic anhydride,benzoic anhydride,polyethyleneimine and 3-chloro-2-hydroxypropyltrimethyl ammonium chloride.Carboxyl,aromatic acyl,polyethyleneimine and quaternary ammonium groups were induced to chitosan chains,and their structure was characterized by FTIR spectra.The adsorption ability of the chemically modified chitosan resins to nine kinds of diuretics was investigated.The results show that,compared to the unmodified chitosan,the benzoyl chitosan has higher affinity and capacity to almost all the diuretics due to the hydrophobic interaction between chitosan and drug molecule,while the carboxyl chitosan has higher binding affinity only to the basic diuretics.The polyethyleneiminated chitosan has 48%～209% higher capacity to the acidic diuretics due to the increased concentration of amino groups on its chain.The adsorption ability of quaternaminated chitosan for the diuretics with carboxyl group is greatly improved,especially for the bumetanide,which is above 2 times higher than the unmodified one because of the strong interaction of ion exchange.; 国家自然科学基金资助项目 (基金号 2 0 2 0 60 12 )
语种	中文 ; 中文
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/64562]
专题	清华大学
推荐引用方式 GB/T 7714	陈飞,骆广生,王玉军,等. 改性壳聚糖树脂对利尿剂的吸附性能[J],2010, 2010.
APA	陈飞,骆广生,王玉军,CHEN Fei,LUO Guangsheng,&WANG Yujun.(2010).改性壳聚糖树脂对利尿剂的吸附性能..
MLA	陈飞,et al."改性壳聚糖树脂对利尿剂的吸附性能".(2010).

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