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	可降解聚氨酯型组织工程多孔支架材料的制备
	姚响 ; 庹新林 ; 王晓工 ; Yao Xiang ; Tuo Xinlin ; Wang Xiaogong
	2010-06-10 ; 2010-06-10
关键词	可降解聚氨酯 组织工程 多孔支架 biodegradable polyurethane tissue engineering porous scaffold O633.14
其他题名	Preparing Biodegradable Polyurethane Porous Scaffold for Tissue Engineering Application
中文摘要	本文在可降解型聚氨酯分子设计,聚氨酯型组织工程支架制备方法,可降解聚氨酯多孔支架的生物学性能及可降解聚氨酯多孔支架在组织工程中的应用等几个方面对可降解聚氨酯型组织工程支架的最新研究进展作了综述。重点讨论了静电纺丝、冷冻干燥、相分离等几种聚氨酯多孔支架制备方法以及聚氨酯型组织工程支架的生物降解性质、生长因子嵌入、生物力学性能、生物相容性等生物学性能。目前的研究表明通过聚氨酯分子设计与各种支架制备方法结合可制得满足各种生物学性能的支架材料且这类材料已被证实在血管、软骨、硬质骨等各类组织工程中有重要的应用价值。但如何进一步提高聚氨酯支架材料的力学强度以使其能更好地与硬组织的力学性能相匹配以及如何降低或消除聚氨酯对人体的毒性仍是需要进一步研究的问题。; Recent developments in some facets for the investigation of biodegradable polyurethane tissue engineering scaffold including biodegradable polyurethane molecular design,fabrication methods of polyurethane tissue engineering scaffold,the biological properties of the biodegradable polyurethane porous scaffold and the application of biodegradable polyurethane porous scaffold in tissue engineering are reviewed.We focus on several polyurethane scaffold preparation methods such as electrostatic spinning,freeze drying,phase separation and some biological properties such as biological degradation property,the imbed of growth factor agent,biological mechanical property and biocompatibility,etc.Recent progress indicates that it is possible to fabricate various kinds of scaffold material which may meet the demand of various kinds of biological properties through the combination of polyurethane molecular design and those scaffold fabrication methods and it has been confirmed that this kind of material has great potential in the application such as vascular,cartilage and bone tissue engineering.However,the mechanical strength of the polyurethane scaffold should be further boosted in order to match the mechanical property of the hard tissue and the toxicity of the polyurethane should be further decreased or eliminated in the future investigation.; 国家高技术发展计划(863)项目(No.2006AA02Z4D4)资助
语种	中文 ; 中文
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/63906]
专题	清华大学
推荐引用方式 GB/T 7714	姚响,庹新林,王晓工,等. 可降解聚氨酯型组织工程多孔支架材料的制备[J],2010, 2010.
APA	姚响,庹新林,王晓工,Yao Xiang,Tuo Xinlin,&Wang Xiaogong.(2010).可降解聚氨酯型组织工程多孔支架材料的制备..
MLA	姚响,et al."可降解聚氨酯型组织工程多孔支架材料的制备".(2010).

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