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	浊点萃取法富集利尿剂Furosemide
	黄焱 ; 秦炜 ; 霍小平 ; 戴猷元 ; HUANG Yan ; QIN Wei ; HUO Xiaoping ; DAI Youyuan
	2010-06-10 ; 2010-06-10
关键词	浊点萃取 利尿剂 富集 cloud point extraction diuretic preconcentration TQ460.6
其他题名	Preconcentration of Furosemide by cloud point extraction
中文摘要	利用表面活性剂C12E10水溶液在温度高于浊点时形成两相的行为对溶液中痕量利尿剂Furosem ide进行了分离特性的研究,考察了盐、表面活性剂、Furosem ide的浓度以及温度的影响。加入硫酸钠可将C12E10溶液的浊点降至常温(20℃),有利于浊点萃取操作。提高盐浓度有利于提高Furosem ide的富集倍数,但对萃取效率几乎没有影响;提高初始溶液中的C12E10浓度将降低Furosem ide富集倍数,提高萃取效率。在30℃~50℃之间,平衡温度的升高有利于提高Furosem ide富集倍数。在温度为40℃时,采用2 g.L-1,C12E10和125 g.L-1硫酸钠体系,富集倍数为165.3倍,相体积比为0.003 7。; A cloud point extraction process (CPE utilizing polyoxyethylene 10 lauryl ether (C_(12E_(10) was developed to extract the diuretic, Furosemide. The effect of the concentrations of sodium sulfate, C_(12E_(10, and Furosemide as well as the temperature on the CPE behavior were investigated. The CPE process was improved by reducing the cloud point of the surfactant solution at ambient temperature with sodium sulfate. The preconcentration factor increases with the salt concentration, but the Furosemide extraction efficiency is independent of the salt concentration. Increasing the initial C_(12E_(10 concentration improves the extraction efficiency, but reduces the preconcentration factor by quickly increasing the coacervate phase mass. The tests also show that the preconcentration factor could be enhanced by increasing the temperature to 30 ℃～50 ℃. A high preconcentration factor of (165.3 and coacervate to aqueous phase volume ratio of 0.003 7 are achieved using 2 g·L~(-1 C_(12E_(10 and 125 g·L~(-1 sodium sulfate at (40 ℃.; 北京市科技三项资助项目(GYYZ0004029040211)
语种	中文 ; 中文
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/63826]
专题	清华大学
推荐引用方式 GB/T 7714	黄焱,秦炜,霍小平,等. 浊点萃取法富集利尿剂Furosemide[J],2010, 2010.
APA	黄焱.,秦炜.,霍小平.,戴猷元.,HUANG Yan.,...&DAI Youyuan.(2010).浊点萃取法富集利尿剂Furosemide..
MLA	黄焱,et al."浊点萃取法富集利尿剂Furosemide".(2010).

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