| 纳米中药制剂 | |
| 罗国安 ; LUO Guo-an | |
| 2010-06-10 ; 2010-06-10 | |
| 关键词 | 中药 纳米 脂质体 聚合物 chinese traditional medicine nanoparticles liposome polymer TQ461 |
| 其他题名 | Study of nano Chinese medicine |
| 中文摘要 | 根据中药成分复杂、选择性低等特点,以纳米技术为平台,建立新型中药传输体系是目前中药现代化研究的热点。近年来,纳米中药制剂的研究在我们实验室取得了可喜的成果。采用反相溶剂蒸发法制备了卡铂脂质体冻干剂,脂质体的粒径为500~700nm,包封率为30%+5%,在-20℃冰箱可稳定6个月。ICP-MS研究表明卡铂脂质体冻干剂主要靶向肺,同时静脉注射后对家兔血管无刺激性反应。采用微乳液聚合制备了载灯盏花素聚丙烯酸酯纳米粒,其平均粒径为50nm,表面电势为-27.2mv,平均包封率为87.57%,体外释放研究表明,直到7h后,药物才全部释放,同普通片剂相比,载药纳米具有一定的缓释效果。在制剂过程中,我们成功建立了用毛细管电泳法,指纹图谱,HPLC和UV等方法来测定纳米体系中药物含量的方法;而且,采用HPLC/MS/MS和HPLC/MS法测定并分析药物在动物体内的代谢行为。另外,我们已开展了秋水仙碱脂质体和雷公藤内酯聚合物纳米制剂等的研究,目前相关工作进展顺利。虽然纳米技术应用于中药制剂的研发工作刚刚起步,但我们相信在不久的将来,纳米中药制剂一定会开创中药制剂的新局面,能创造更好的社会效益和经济效益。; At present, there has been considerable interest in developing and establishing novel Chinese Traditional Medicine Delivery System (CTMDS) by nano-Science Technology (Nano-ST) according to the properties of CTM, such as mutli-components and poor selectivity. Some delightful achievements have been obtained about nano-CTM in our researching group in recent years. Liposomal carboplatin sterilized powder were successfully prepared by reverse phase solvent evaporation method and characterized Dynamic Light Scattering (DLS) and Transmission Electron Microscope (TEM). The nanoparticles produced were a spherical shape with smooth surface, a mean size of 500 nm ~ 700 nm and the encapsulation efficiency of 30+5 %. The particles were not change at -20℃ refrigeratory for six months. Liposomal carboplatin mainly targeted to lung by ICP-MS analysis. There were not stimulating responses to the blood vessel of rabbit by infecting liposomal carboplatin. Meanwhile, breviscapines-loaded poly (methacrylate) nanoparticles were successfully prepared by the emulsi-polymerization method. The nanoparticles obtained were a mean size of 50 nm, the mean encapsulation efficiency of 87.57% and the ξ of -27.2 mv. Breviscapines were released from nanoparticles untile total 7 h. So breviscapines-loaded poly (methacrylate) nanoparticles have a degree slowly release effect compared to its troche. The methods, which drug amounts into nanoparticles were determined by Capillary Electrophoresis (CE), Fingerprint Spectrum (FPS), HPLC and UV in nanoparticles systems, were successfully established in our experiment. The metabolic behaviors of drug in animals were determined and analyzed by HPLC/MS/MS and HPLC/MS methods. In addition, we have been developing study on the liposomal colchicines and the lactone mixture of Tripterygium Wilfordii Hook. f. loaded polymer nanoparticles in our researching group. Although there are a lot of difficulties to research and develop CTM with a help of Nano-ST, there is a better future to achieve a preferable society and economy benefit about nano-CTM. |
| 语种 | 中文 ; 中文 |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/60823]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | 罗国安,LUO Guo-an. 纳米中药制剂[J],2010, 2010. |
| APA | 罗国安,&LUO Guo-an.(2010).纳米中药制剂.. |
| MLA | 罗国安,et al."纳米中药制剂".(2010). |
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