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	性别和年龄对中国人冠状动脉旁路移植术后住院病死率的影响
	宫路佳 ; Elke Lehmkuhl ; 胡盛寿 ; Friederike Kendel ; Stein Kandle ; Yong Du ; 章晏 ; 杜茗 ; 吴清玉 ; 许建屏 ; 孙立忠 ; 朱晓东 ; Vera Regitz-Zagrosek ; GONG Lu-jia ; Elke Lehmkuhl ; HU Sheng-shou ; Friederike Kendel ; Stein Kandle ; Yong Du ; ZHANG Yan ; DU Ming ; WU Qing-yu ; XU Jian-ping ; SUN Li-zhong ; ZHU Xiao-dong ; Vera Regitz-Zagrosek
	2010-06-09 ; 2010-06-09
关键词	冠状动脉分流术 性别 年龄 医院死亡率 Coronary artery bypass Gender Age Hospital mortality R654.2
其他题名	Impact of gender and age on in-hospital mortality after coronary artery bypass graft
中文摘要	目的确定中国人冠状动脉旁路移植术后住院病死率是否存在性别差异以及该差异是否与年龄相关。方法回顾性分析1997年1月1日至2001年12月31日阜外心血管病医院外科全部接受冠状动脉旁路移植术的患者共2682例(男性2316例,女性366例)。按照性别和年龄分组调查它们之间的围手术期并发症及手术后住院病死率的差异。结果女性术前合并主要疾病的比例比男性高,术后并发症多,但她们术前的左心室射血分数较男性好,且冠状动脉病变数量少。然而,女性患者的术后住院病死率是男性的3倍(女性3.01%,男性1.12%,P=0.001),病死率的性别差异在低龄组更有统计学意义(女性2.6%,男性0.5%,P=0.001,ORs4.844,95%可信区间1.549~15.142),在老年患者中则无统计学意义(女性3.7%,男性2.4%,P=0.383)。结论中国女性冠状动脉旁路移植术的住院病死率高于男性,特别是低龄女性。低龄组女性是住院病死率的独立危险因素。死亡率的性别差异随年龄增加而减少。需要进一步的研究来阐明病死率的性别差异在低龄组更显著的原因。; Objective The purpose of this study was to explore the association of gender and age on in-hospital mortality after coronary artery bypass graft (CABG) among the Chinese population.Methods A total of 2682 patients (male: 2316, female: 366) who underwent CABG surgery were retrospectively investigated between January 1st, 1997 and December 31st, 2001 for perioperative risk factors and in-hospital mortality rate after CABG.Results Preoperative comorbidity rate and postoperative complication rate were higher in women than that in men, although left ventricular ejection fraction was higher and the number of diseased vessels fewer in women than in men. The in-hospital mortality rate was three times higher in women than that in men (3.01% vs. 1.12%, P=0.001), especially in the younger age group (2.6% vs. 0.5%, P=0.001, risk-adjusted odds ratio 4.844, 95%CI: 1.549-15.142). In older patients, there was no notable difference in in-hospital mortality between the genders (3.7% for women vs. 2.4% for men, P=0.383).Conclusions Chinese woman, especially in younger age, had a higher in-hospital mortality rate post CABG than that in men, suggesting that younger female gender is an independent risk factor for in-hospital mortality after CABG. Future studies are warranted to clarify the underlying mechanisms.; 科技部社会公益研究资金资助(课题名称:心脑血管及主要恶性肿瘤诊治技术规范化操作规程及评价体系研究,编号:2002DIB40092)
语种	中文 ; 中文
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/59009]
专题	清华大学
推荐引用方式 GB/T 7714	宫路佳,Elke Lehmkuhl,胡盛寿,等. 性别和年龄对中国人冠状动脉旁路移植术后住院病死率的影响[J],2010, 2010.
APA	宫路佳.,Elke Lehmkuhl.,胡盛寿.,Friederike Kendel.,Stein Kandle.,...&Vera Regitz-Zagrosek.(2010).性别和年龄对中国人冠状动脉旁路移植术后住院病死率的影响..
MLA	宫路佳,et al."性别和年龄对中国人冠状动脉旁路移植术后住院病死率的影响".(2010).

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