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	新生儿出生时脑氧合及血流改变的近红外光谱研究
	侯新琳 ; 杨慧霞 ; 周丛乐 ; 丁海曙 ; 吴成 ; 丁海艳 ; HOU Xin-lin ; YANG Hui-xia ; ZHOU Cong-le ; DING Hai-shu ; WU Cheng ; DING Hai-yan
	2010-06-09 ; 2010-06-09
关键词	脑氧合 脑血流 近红外光谱 新生儿 Brain oxygenation Cerebral blood flow Near infrared spectroscopy Newborn R722.1
其他题名	The study of brain oxygenation and cerebral blood flow in post-birth newborns using near infrared spectroscopy
中文摘要	目的研究正常新生儿出生后脑氧合及血流的变化规律,以及宫内窘迫、妊娠高血压疾病、妊娠糖尿病对初生新生儿脑氧合及血流的影响。方法用近红外光谱技术检测初生新生儿脑组织还原血红蛋白浓度CHb和氧合血红蛋白浓度CHbO2的变化值及反应脑氧合的氧饱和度rSO2绝对值,进一步得到反应脑血容量的CtHb=CHb+CHbO2,反应脑灌注的CHbD=CHbO2-CHb。结果正常新生儿出生后2~5分钟,rSO2呈上升的趋势;CtHb相对稳定;CHbD呈上升的趋势。母亲合并妊娠高血压疾病的新生儿生后4~5分钟脑血流CtHb明显高于正常儿,P<0.05;生后2~5分钟脑灌注CHbD明显低于正常足月儿,P<0.05。母亲合并妊娠糖尿病的新生儿生后4~5分钟脑血流CtHb明显高于正常儿。宫内窘迫的新生儿rSO2、CtHb、CHbD的变化规律接近足月儿。结论正常新生儿出生后2~5分钟,脑氧合增加,脑血流稳定、脑灌注增加。妊娠高血压疾病对脑灌注的影响延续至生后5分钟。经过积极的产科处理,宫内窘迫和妊娠糖尿病对新生儿脑氧合及灌注影响不大。; Objective To study the changing patterns of brain oxygenation and cerebral blood flow in normal post-birth newborns and understand the influences of intrauterine distress,pregnancy-induced hypertension syndrome and gestational diabetes mellitus upon the brain oxygenation and cerebral blood flow in early newborns.Methods The authors employed the technology of NIRS(near infrared spectroscopy)monitor the change values of CHb,CHbO2 and the absolute values rSO2 in newborn brain,the reacting brain blood volume of CtHb=CHb+CHbO2 and brain perfusion CHbD= CHbO2-CHb was further obtained.Results At 2~5min in normal newborns,the trends of rSO2、CHbD were rising,the CtHb were stable respectively.At 2~5min post-birth in newborns whose mothers were complicated with pregnancy-induced hypertension syndrome,the CtHb at 4~5min were high than normal newborn,there were significant differences between them.The CHbD was lower than the normal controls at 2~5min post-birth,there were significant differences between them.In the newborns whose mothers were complicated with diabetes mellitus,the CtHb at 4~5min were high than normal newborn,there were significant differences between them.Intrauterine distress caused no major changes of rSO2、CtHb、CHbD in early newborns.Conclusion At 2~5min post-birth in normal newborns,brain oxygenation increased,brain flow stable,brain perfusion increased.The effects of pregnancy-induced hypertension syndrome extended until 5min post-birth.After active obstetric interventions,intrauterine distress and gestational diabetes mellitus had no major influences upon neonate brain oxygenation and perfusion.; 国家自然科学基金(60578004); 中国博士后基金(20060390476)
语种	中文 ; 中文
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/58446]
专题	清华大学
推荐引用方式 GB/T 7714	侯新琳,杨慧霞,周丛乐,等. 新生儿出生时脑氧合及血流改变的近红外光谱研究[J],2010, 2010.
APA	侯新琳.,杨慧霞.,周丛乐.,丁海曙.,吴成.,...&DING Hai-yan.(2010).新生儿出生时脑氧合及血流改变的近红外光谱研究..
MLA	侯新琳,et al."新生儿出生时脑氧合及血流改变的近红外光谱研究".(2010).

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