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	应用近红外光谱技术评价早产儿认知功能的探讨
	侯新琳 ; 周丛乐 ; 黄岚 ; 丁海曙 ; 汤泽中 ; 姜毅 ; HOU Xin-Lin ; ZHOU Cong-Le ; HUANG Lan ; DING Hai-Shu ; TANG Ze-Zhong ; JIANG Yi.
	2010-06-09 ; 2010-06-09
关键词	认知 脑反应性 近红外光谱 婴儿,早产 Cognition Cerebral oxygenation response Near infrared spectroscopy Light stimulation Infant, preterm R722.6
其他题名	Evaluation of early cognitive ability of infants born preterm by near-infrared spectroscopy
中文摘要	目的通过建立对早产儿光刺激后的反应模式,评价早产儿早期的认知功能,研究早产儿在发育过程中的脑反应性与足月儿之间的差距。方法对纠正胎龄3个月、6个月的早产儿进行光刺激,应用近红外光谱技术,观察光刺激后脑反应性的变化,并与同龄儿对照。结果早产儿在纠正胎龄3个月时,光刺激后开始反应时间、反应高峰出现的时间分别为17.2±5.2s、38.4±9.6s,明显长于足月儿的13.1±2.7s、28.9±5.0s;脑组织还原血红蛋白、氧合血红蛋白、脑组织氧饱和度在刺激后的最大反应值分别为(1.2±0.5)%、(1.5±0.6)%、(1.3±0.4)%,明显低于足月儿的(2.3±0.3)%、(2.8±0.3)%、(2.4±0.5)%。到了纠正胎龄6个月时,光刺激后的脑反应性与足月儿相比,无统计学差异。结论早产儿在发育过程中,认知功能存在一定的滞后,到纠正胎龄3个月时,外界刺激后的脑反应性仍落后于同龄儿,到了纠正胎龄6个月时,脑反应性接近同龄儿,应加强对早产儿的早期干预。; Objective To compare the differences in cerebral oxygenation responses between the infants born preterm and full-term infants and to evaluate the early cognitive ability of infants born preterm. Methods Cerebral oxygenation after light stimulation was detected by near infrared spectroscopy (NIRS) in preterm infants at 3 or 6 months corrected gestational age (GA). The results were compared with those of age-matched infants born at term. Results The start and peak response time of cerebral oxygenation occurring after light stimulation in preterm infants at 3 months corrected GA was 17.2�2 and 38.4�6 seconds respectively, which were significantly longer than in age-matched term infants (13.1� 2.7 and 28.9�0 seconds respectively) (P<0.05). The maximum response value of hemoglobin, oxyhemoglobin and regional oxygen saturation of the preterm infants at 3 months corrected GA was (1.2�5)%, (1.5�6)%, and (1.3�4) % respectively , which were significantly lower than that of the term infants [(2.3�3)%, (2.8�3)%and (2.4�5)% respectively] (P<0.05). Cerebral oxygenation responses to light stimulation in preterm infants examined at 6 months corrected GA were not significantly different from age-matched term infants. Conclusions Cerebral oxygenation responses to light stimulation in infants born preterm at 3 months corrected GA are not as good as age-matched term infants, but were close to the level of age-matched term infants at 6 months corrected GA. This suggests that the early cognitive ability of preterm infants before 3 months corrected GA might fall behind age-matched term infants.
语种	中文 ; 中文
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/58388]
专题	清华大学
推荐引用方式 GB/T 7714	侯新琳,周丛乐,黄岚,等. 应用近红外光谱技术评价早产儿认知功能的探讨[J],2010, 2010.
APA	侯新琳.,周丛乐.,黄岚.,丁海曙.,汤泽中.,...&JIANG Yi..(2010).应用近红外光谱技术评价早产儿认知功能的探讨..
MLA	侯新琳,et al."应用近红外光谱技术评价早产儿认知功能的探讨".(2010).

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