| 大豆苷元-羟丙基-β-环糊精包合物的研究 | |
| 葛月宾 ; 陈大为 ; 谢莉萍 ; 王洪钟 ; 郑桂兰 ; 张荣庆 ; GE Yue-bin ; CHEN Da-wei ; XIE Li-ping ; WANG Hong-zhong ; ZHENG Gui-lan ; ZHANG Rong-qing | |
| 2010-06-07 ; 2010-06-07 | |
| 关键词 | 大豆苷元 羟丙基-β-环糊精包合物 溶液搅拌法 daidzein hydropropyl-β-cyclodextrin solution stirring method R284.1 |
| 其他题名 | Preparation of inclusion complex of daidzein and hydropropyl-β-cyclodextrin |
| 中文摘要 | 目的：制备难溶性药物大豆苷元的羟丙基-β-环糊精包合物,提高其水溶性。方法：采用溶液搅拌法制备包合物,并对包合物进行差示热分析和热重分析、红外光谱、粉末X-射线衍射分析鉴定,最后测定了包合物的稳定常数。结果：在选定条件下制备的包合物中药物含量为6．76%,溶解度为13．68 mg·mL~(-1),3种鉴定方法的结果证实形成了包合物。结论：大豆苷元-羟丙基-β-环糊精包合物的制备方法简单可行,达到了增加药物溶解度的目的。; Objective:To prepare an inclusion complex of daidzein and hydropropyl-β-cyclodextrin to enhance the solubility of daidzein.Method:The inclusion complex of daidzein was prepared by the solution stirring method.The binary system of daidzein and HP-β-CD was confirmed by differential thermal,thermogravimetry analysis,infrared spectroscopy and X-ray diffractometry.Result:The drug content in the inclusion complex was 6.76% and the solubility was 13.68 mg·mL~(-1)The identification results showed that the inclusion complex was formed.Conclusion:The preparation method of the inclusion complex of daidzein and hydropropyl-β-cyclodex- trin is simple and available,with a increased solubility of daidzein. |
| 语种 | 中文 ; 中文 |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/45726]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | 葛月宾,陈大为,谢莉萍,等. 大豆苷元-羟丙基-β-环糊精包合物的研究[J],2010, 2010. |
| APA | 葛月宾.,陈大为.,谢莉萍.,王洪钟.,郑桂兰.,...&ZHANG Rong-qing.(2010).大豆苷元-羟丙基-β-环糊精包合物的研究.. |
| MLA | 葛月宾,et al."大豆苷元-羟丙基-β-环糊精包合物的研究".(2010). |
| 个性服务 |
| 查看访问统计 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论