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	仿生双相磷酸钙生物陶瓷支架的Micro-CT评价
	彭江 ; 汪爱媛 ; 孙明学 ; 卢世璧 ; 赵斌 ; 许文静 ; 田杰谟 ; 董利民 ; PENG Jiang ; WANG Ai-yuan ; SUN Ming-xue
	2010-06-04 ; 2010-06-04
关键词	组织工程支架 骨小梁 三维空间结构 股骨头 Micro-CT Trabecula Three-dimensional Space structure Tissue engineering Scaffold Micro-CT R318.08
其他题名	The Three-Dimensional evaluation of biomimetic biphasic calcium phosphate(BCP) scaffold
中文摘要	[目的]体外用MicroCT(Microcomputedtomography)图像对仿生双相磷酸钙生物陶瓷支架的三维结构进行计算机重建和评价。[方法]犬股骨头的松质骨样本行MicroCT扫描,提取图像信息;三维凝胶叠层成型法制备出具有仿骨小梁结构的双相磷酸钙仿生生物陶瓷支架。随后用MicroCT对支架扫描,以三维结构参数对支架和松质骨样本作三维评价和比较。三维参数包括骨体积分数(BoneVolumeFraction,BVF,BV/TV)、骨表面积体积比(Bonesurface/bonevolumeratio,BS/BV)、骨小梁厚度(Trabecularthickness,TbTh)、骨小梁数目(Trabecularnumber,TbN)、骨小梁间隙(Trabecularspacing,TbSp)、结构模型指数(StructureModelIndex,SMl)和各向异性程度(degreeofanisoropy,DA)。[结果]与犬股骨头松质骨样本相比,用本方法制备出的BCP支架具有相似的三维空间结构,二者的BV/TV、TbTh、TbN无显著差别(P>0.05)。小梁结构呈板状模型。[结论]本研究制备的BCP多孔支架的小梁具有一定的取向性,力学强度和良好的适于血管长入的空间结构。; [Objective]To evaluated the structure of biomimetic biphasic calcium phosphate(BCP) ceramic scaffolds by their images of the micro-computed tomography(Micro-CT).[Method] Series of two-dimensional images of femoral head's specimen of dogs were obtained by Micro-CT.According to these images,porous biomimetic biphasic calcium phosphate(BCP) ceramic scaffolds were fabricated by three-dimensional(3D) gel-lamination technology.And then,the three-dimensional structure of the scaffolds were reconstructed by computer according to Micro-CT images of these scaffolds and evaluated by three-dimensional parameters.These parameters included bone volume fraction (BVF,BV/TV),bone surface/bone volume (BS/BV) ratio,trabecular thickness (Tb.Th),trabecular number (Tb.N),trabecular spacing (Tb.Sp),structure model index (SMI) and degree of anisotropy(DA).The biomechanical properties and compatibility of these scaffolds were also evaluated.[Result] There was no significant difference between trabecular samples and BCP scaffolds in BV/TV,Tb.Th,Tb.N,and Tb.Pf (P> 0.05 ).The trabecular system of the scaffold,which had some orientation,represented plate-like model.[Conclusion]Porous BCP scaffolds have been produced with oriented microarchitectural features designed to facilitate vascular invasion and cellular attachment and with initial mechanical properties comparable to those of trabecular bone.; 国家自然科学基金重点项目(项目编号;30330570)
语种	中文 ; 中文
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/35688]
专题	清华大学
推荐引用方式 GB/T 7714	彭江,汪爱媛,孙明学,等. 仿生双相磷酸钙生物陶瓷支架的Micro-CT评价[J],2010, 2010.
APA	彭江.,汪爱媛.,孙明学.,卢世璧.,赵斌.,...&SUN Ming-xue.(2010).仿生双相磷酸钙生物陶瓷支架的Micro-CT评价..
MLA	彭江,et al."仿生双相磷酸钙生物陶瓷支架的Micro-CT评价".(2010).

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