| 颅骨修补材料钛金属表面梯度生物活性涂层的生物相容性研究 | |
| 叶迅 ; 赵元立 ; 朱琳 ; 唐光昕 ; 李朝征 ; 李京生 ; 于书卿 ; 赵继宗 ; YE Xun ; ZHU Lin ; TANG Guang-xi ; Li Chao-zheng ; Li Jing-sheng ; Yu Shu-qing ; Zhao Ji-zong | |
| 2010-05-14 ; 2010-05-14 | |
| 关键词 | 颅骨修补材料 钛金属 羟基磷灰石涂层 生物相容性 Skull repair material Titanium Hydroxyapitate gradient coating Biocompatibility R318.08 |
| 其他题名 | Biocompatibility study of the gradient bioactive coating prepared on titanium |
| 中文摘要 | 目的评价复合氧化及水热沉淀法制备纯钛表面梯度生物活性涂层材料的生物相容性。方法分别通过体外细胞相容性实验和动物皮下植入实验综合评估复合氧化及水热沉淀法制备的梯度羟基磷灰石(hydroxyapitate,HA)涂层的生物相容性。结果体外细胞相容性实验(MTT法)显示,各组材料对L929细胞的生长、增殖、代谢无不良影响。在不同时间点上,羟基磷灰石改性试件表面的光吸收值均比纯钛试件有所增加,在细胞接种后期增加尤为显著,提示羟基磷灰石改性试件的细胞相容性优于其它各组试件。动物皮下植入实验结果显示各组材料30d后,炎性细胞反应程度、囊壁形成情况、周边组织反应均﹤I级,符合GB/T16886.6-1997医疗器械生物学评价I级标准,其中羟基磷灰石组在纤维囊壁成熟方面更优于其它组。结论复合氧化及水热沉淀法制备纯钛表面梯度生物活性涂层材料具有良好的生物相容性,值得作为颅骨修补材料进一步研究。; Objective To evaluate the biocompatibility of the composite-preparing gradient bioactive coating on titanium. Methods Cell culture and MTT tests were used to evaluate the cell biocompatibility of this new coating material. It was implanted into rabbits subcutaneously and histological evaluation of the interface was carried out. According to GB/ T16886.6 -1997 standard, the histological observation and comparative evaluation were done in the following aspects : inflamation, fibrocystic formation and interaction with surrounding tissue. Results More L929 fibro-sarcoma cells attached and proliferated on the HA coating material surface than titanium surface. The implanted study showed that the tissue reaction with hydroxyapatite coating material was milder than titanium and other samples. The results of in vitro study show that the gradient bioactive coatings has very good cell compatibility to the L929 fibro-sarcoma cells. The gradient bioactive coatings also exhibites excellent tissue compatibility after being implanted in rabbits subcutaneously. Conclusions The composite-preparing gradient bioactive coating on titanium has good biocompatibility. The gradient bioactive coatings are suitable for skull repair. |
| 语种 | 中文 ; 中文 |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/33894]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | 叶迅,赵元立,朱琳,等. 颅骨修补材料钛金属表面梯度生物活性涂层的生物相容性研究[J],2010, 2010. |
| APA | 叶迅.,赵元立.,朱琳.,唐光昕.,李朝征.,...&Zhao Ji-zong.(2010).颅骨修补材料钛金属表面梯度生物活性涂层的生物相容性研究.. |
| MLA | 叶迅,et al."颅骨修补材料钛金属表面梯度生物活性涂层的生物相容性研究".(2010). |
| 个性服务 |
| 查看访问统计 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论