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	The expression and the role of protease nexin-1 on brain edema after intracerebral hemorrhage
	Wu, He ; Zhao, Ruibo ; Qi, Jiping ; Cong, Yuwei ; Wang, Dandan ; Liu, Tao ; Gu, Yunhe ; Ban, Xiang ; Huang, Qi
	2010-05-11 ; 2010-05-11
关键词	PN-1 thrombin AQP-4 cerebral edema intracerebral hemorrhage NEURITE-PROMOTING FACTOR MESSENGER-RNA EXPRESSION FOCAL CEREBRAL-ISCHEMIA GLIA-DERIVED NEXIN RAT-BRAIN PLASMINOGEN-ACTIVATOR BARRIER PERMEABILITY CEREBROSPINAL-FLUID INHIBITORY ACTIVITY ALZHEIMER-DISEASE Clinical Neurology Neurosciences
中文摘要	Brain edema is one of the most frequent and serious complications of intracerebral hemorrhage (ICH), but how the ICH cause brain edema is unknown. Our studies were designed to investigate the regulation and distribution of protease nexin-1 (PN-1), thrombin and aquaporin-4 (AQP-4) in brain edema after ICH in rat and human brain in vivo. Our result showed that the severity of cerebral edema resulted from an acute stage of ICH. The PN-1-thrombin system modulated cerebral edema after ICH. Thrombin and AQP-4 increased to aggregate cerebral edema after ICH. In order to control the deleterious effect of thrombin's overexpression, PN-1 appeared quickly and abundantly to inhibit thrombin and lessen the cerebral edema. PN-1 was distributed in neurons and glial cells of cerebral cortex, hippocampus, thalamencephalon, basal ganglia, cerebellum and circum-encephalocoele in rat and human brain. The expression of AQP-4 is different between human and rat. Thus, we demonstrated that the animal experimental approach was, however, not sufficient by itself and needed to be corroborated by observations on human brains. (C) 2008 Elsevier B.V. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER SCIENCE BV ; AMSTERDAM ; PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/27767]
专题	清华大学
推荐引用方式 GB/T 7714	Wu, He,Zhao, Ruibo,Qi, Jiping,et al. The expression and the role of protease nexin-1 on brain edema after intracerebral hemorrhage[J],2010, 2010.
APA	Wu, He.,Zhao, Ruibo.,Qi, Jiping.,Cong, Yuwei.,Wang, Dandan.,...&Huang, Qi.(2010).The expression and the role of protease nexin-1 on brain edema after intracerebral hemorrhage..
MLA	Wu, He,et al."The expression and the role of protease nexin-1 on brain edema after intracerebral hemorrhage".(2010).

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