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	Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis
	Liu, Z ; Lin, H ; Ye, S ; Liu, QY ; Meng, Z ; Zhang, CM ; Xia, Y ; Margoliash, E ; Rao, Z ; Liu, XJ
	2010-05-11 ; 2010-05-11
关键词	mouse testis antioxidation OXIDATIVE STRESS HYDROGEN-PEROXIDE HUMAN-SPERMATOZOA MALE-INFERTILITY HUMAN GENOME MITOCHONDRIA GENERATION SPERM SITE INITIATION Multidisciplinary Sciences
中文摘要	Hydrogen peroxide (H2O2) is the major reactive oxygen species (ROS) produced in sperm. High concentrations of H2O2 in sperm induce nuclear DNA fragmentation and lipid peroxidation and result in cell death. The respiratory chain of the mitochondrion is one of the most productive ROS generating systems in sperm, and thus the destruction of ROS in mitochondria is critical for the cell. It was recently reported that H2O2 generated by the respiratory chain of the mitochondrion can be efficiently destroyed by the cytochrome c-mediated electron-leak pathway where the electron of ferrocytochrome c migrates directly to H2O2 instead of to cytochrome c oxidase. In our studies, we found that mouse testis-specific cytochrome c (T-Cc) can catalyze the reduction of H2O2 three times faster than its counterpart in somatic cells (S-Cc) and that the T-Cc heme has the greater resistance to being degraded by H2O2. Together, these findings strongly imply that T-Cc can protect sperm from the damages caused by H2O2. Moreover, the apoptotic activity of T-Cc is three to five times greater than that of S-Cc in a well established apoptosis measurement system using Xenopus egg extract. The dramatically stronger apoptotic activity of T-Cc might be important for the suicide of male germ cells, considered a physiological mechanism that regulates the number of sperm produced and eliminates those with damaged DNA. Thus, it is very likely that T-Cc has evolved to guarantee the biological integrity of sperm produced in mammalian testis.
语种	英语 ; 英语
出版者	NATL ACAD SCIENCES ; WASHINGTON ; 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/27752]
专题	清华大学
推荐引用方式 GB/T 7714	Liu, Z,Lin, H,Ye, S,et al. Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis[J],2010, 2010.
APA	Liu, Z.,Lin, H.,Ye, S.,Liu, QY.,Meng, Z.,...&Liu, XJ.(2010).Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis..
MLA	Liu, Z,et al."Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis".(2010).

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