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	Tetracycline controlled CHIP expression inhibits TGF-beta signal pathway
	Xu, XL ; Xin, H ; Zhang, XJ ; Ren, FL ; Wang, YY ; Chang, ZJ
	2010-05-11 ; 2010-05-11
关键词	tetracycline control CHIP transforming growth factor-beta (TGF-beta) Smad2/3 JunB inhibition HEAT-SHOCK PROTEINS DEGRADATION TRANSCRIPTION COACTIVATOR INTERACTS COMPLEX SMAD3 Biochemistry & Molecular Biology Biophysics
中文摘要	To investigate the regulatory function of chaperone interacting protein CHIP in TGF-beta signal pathway, a tetracycline induced CHIP expression stable cell line (Mv1Lu-Tet off-CHIP) was generated. In this cell line model, it was observed that overexpression of CHIP dramatically reduced the endougenous Smad2/3 protein level. Luciferase reporter analysis showed that CHIP inhibited the Smads induced transcription activity. Furthermore, Western blot results indicated that CHIP could downregulate gene expression of JunB, a quick response gene induced by TGF-beta. These results provided new evidences that CHIP might be a novel signal protein negatively regulating TGF-beta signal pathway.
语种	中文 ; 中文
出版者	SCIENCE PRESS ; BEIJING ; 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/27733]
专题	清华大学
推荐引用方式 GB/T 7714	Xu, XL,Xin, H,Zhang, XJ,et al. Tetracycline controlled CHIP expression inhibits TGF-beta signal pathway[J],2010, 2010.
APA	Xu, XL,Xin, H,Zhang, XJ,Ren, FL,Wang, YY,&Chang, ZJ.(2010).Tetracycline controlled CHIP expression inhibits TGF-beta signal pathway..
MLA	Xu, XL,et al."Tetracycline controlled CHIP expression inhibits TGF-beta signal pathway".(2010).

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