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	Model of depressed myocardium shows orthostatic intolerance with or without reduced blood volume
	Hao, WY ; Bai, J ; Zhang, LF ; Wu, XY ; Ying, K
	2010-05-11 ; 2010-05-11
关键词	lower body negative pressure computer simulation orthostatic tolerance orthostatic hypotension spaceflight heart BODY NEGATIVE-PRESSURE CARDIOVASCULAR-RESPONSE SIMULATED MICROGRAVITY CARDIAC ATROPHY BED-REST HYPOTENSION STRESS CONTRACTILITY SPACEFLIGHT MECHANISM Public, Environmental & Occupational Health Medicine, General & Internal Sport Sciences
中文摘要	Introduction: The development of orthostatic hypotension (OH) is complex and multi-factorial. Previous simulation work indicates that myocardial contractility depression (MCD) may increase OH when there is a total blood volume decrease. This paper hypothesized that MCD increased CH in both humans with and without decrease in blood volume. Methods: A model, which was previously used to reproduce cardiovascular response to lower body negative pressure (LBNP), hypovolemia, and MCD, was modified by incorporating the physiologic mechanism of plasma filtration into the interstitium during LBNP. The model was evaluated by human experimental results. Using the model, HR and BP response to LBNP were simulated at conditions of 10%, 20%, and 30% MCD. Additionally, HR and BP response to LBNP were simulated at conditions of 10% and 20% MCD with a 12% decrease in blood volume. Results: Simulation results indicate that the increments of HR and decrements of systolic BP (SBP) and mean arterial pressure (MAP) rise with the increases of MCD. Specifically, simulation results indicate that about 30% MCD would cause OH (HR: 117 bpm; SBP: 92 mmHg; MAP: 78 mmHg). It also indicates that about 20% MCD would cause CH (HR: 134 bpm, SBP: 84 mmHg, MAP: 73 mmHg) with a 12% decrease in total blood volume. Conclusion: It is suggested that MCD increases OH whether or not there is a total blood decrease, and further suggested that MCD induced by both spaceflight and heart disease may increase CH.
语种	英语 ; 英语
出版者	AEROSPACE MEDICAL ASSOC ; ALEXANDRIA ; 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/27624]
专题	清华大学
推荐引用方式 GB/T 7714	Hao, WY,Bai, J,Zhang, LF,et al. Model of depressed myocardium shows orthostatic intolerance with or without reduced blood volume[J],2010, 2010.
APA	Hao, WY,Bai, J,Zhang, LF,Wu, XY,&Ying, K.(2010).Model of depressed myocardium shows orthostatic intolerance with or without reduced blood volume..
MLA	Hao, WY,et al."Model of depressed myocardium shows orthostatic intolerance with or without reduced blood volume".(2010).

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