QQ客服 官方微博 反馈留言

	Neutralizing epitopes in the membrane-proximal region of HIV-1 gp41: Genetic variability and co-variation
	Dong, Xiao-Nan ; Chen, Ying-Hua
	2010-05-11 ; 2010-05-11
关键词	HIV-1 gp41 neutralizing epitopes genetic variability co-variation IMMUNODEFICIENCY-VIRUS TYPE-1 HUMAN MONOCLONAL-ANTIBODIES CROSS-CLADE NEUTRALIZATION PHASE-I INFECTION GLYCOPROTEIN SUBTYPES STRAINS Immunology
中文摘要	Recent investigations on the passive immunization have proved that neutralizing antibodies directed to the membrane-proximal region of HIV-1 gp4l are potent anti-viral components, so this region is thought to be an attractive target for AIDS vaccine. Three key neutralizing epitopes, ELDKWA (aa662-667), NWFDIT (aa671-676) and ERDRDR (aa739-744) have been mapped in this region. In this study, their genetic variability and co-variation was evaluated. There exists marked shift in the predominant sequence patterns on these three neutralizing epitopes over time. Compared with subtype B, non-B clades exhibit significant genetic variability and co-variation on these three epitopes. Among HIV-1 strains isolated in recent 5 years, about one third displays epitope variants simultaneously on three epitopes. The newly isolated strains with co-variations on several neutralizing epitopes ought to be of strict surveillance in clinical treatment, and those frequent epitope variants should also be considered in vaccine design. (c) 2006 Elsevier B.V. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER SCIENCE BV ; AMSTERDAM ; PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/27031]
专题	清华大学
推荐引用方式 GB/T 7714	Dong, Xiao-Nan,Chen, Ying-Hua. Neutralizing epitopes in the membrane-proximal region of HIV-1 gp41: Genetic variability and co-variation[J],2010, 2010.
APA	Dong, Xiao-Nan,&Chen, Ying-Hua.(2010).Neutralizing epitopes in the membrane-proximal region of HIV-1 gp41: Genetic variability and co-variation..
MLA	Dong, Xiao-Nan,et al."Neutralizing epitopes in the membrane-proximal region of HIV-1 gp41: Genetic variability and co-variation".(2010).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。