Integrated genome-wide gene expression map and high-resolution analysis of aberrant chromosomal regions in squamous cell lung cancer | |
Zhang, XY ; Hu, Y ; Cui, YP ; Miao, XP ; Tian, F ; Xia, YJ ; Wu, YQ ; Liu, XJ | |
2010-05-11 ; 2010-05-11 | |
关键词 | microarray aberrant chromosomal region squamous cell carcinoma gene expression map moving-median method HYBRIDIZATION ANALYSIS ALLELIC IMBALANCE DISTINCT PATTERNS HIGH-LEVEL ADENOCARCINOMA CARCINOMAS HETEROZYGOSITY IDENTIFICATION MICROARRAYS FREQUENT Biochemistry & Molecular Biology Biophysics Cell Biology |
中文摘要 | The recognition of recurrent aberrant regions in cancer is important to the discovery of candidate cancer related genes. Here we first constructed a genome-wide gene expression map of squamous lung carcinoma from the Stanford Microarray Database. High-resolution detection of aberrant chromosomal regions was performed by using moving-median method. 84% (27 of 32) of our results were consistent with the previous studies of comparative genomic hybridization or loss of heterozygosity. One overrepresented region in Xq28 was newly discovered to be related to squamous cell lung carcinoma. These observations could be of great interest for further studies. (c) 2006 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. |
语种 | 英语 ; 英语 |
出版者 | ELSEVIER SCIENCE BV ; AMSTERDAM ; PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
内容类型 | 期刊论文 |
源URL | [http://hdl.handle.net/123456789/27030] ![]() |
专题 | 清华大学 |
推荐引用方式 GB/T 7714 | Zhang, XY,Hu, Y,Cui, YP,et al. Integrated genome-wide gene expression map and high-resolution analysis of aberrant chromosomal regions in squamous cell lung cancer[J],2010, 2010. |
APA | Zhang, XY.,Hu, Y.,Cui, YP.,Miao, XP.,Tian, F.,...&Liu, XJ.(2010).Integrated genome-wide gene expression map and high-resolution analysis of aberrant chromosomal regions in squamous cell lung cancer.. |
MLA | Zhang, XY,et al."Integrated genome-wide gene expression map and high-resolution analysis of aberrant chromosomal regions in squamous cell lung cancer".(2010). |
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