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	Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2
	Yang, G ; Gong, YD ; Gong, K ; Jiang, WL ; Kwon, E ; Wang, P ; Zheng, H ; Zhang, XF ; Gan, WB ; Zhao, NM
	2010-05-11 ; 2010-05-11
关键词	Alzheimer's disease amyloid precursor protein amyloid precursor-like protein electron microscopy submandibular ganglion ALZHEIMERS-DISEASE TRANSGENIC MICE NEUROMUSCULAR-JUNCTION AXONAL-TRANSPORT SYNAPSES HOMOLOG APLP2 IDENTIFICATION LOCALIZATION GANGLION Neurosciences
中文摘要	Although abnormal processing of amyloid precursor protein (APP) leads to early onset of Alzheimer's disease, the normal function of this protein is poorly understood. APP is widely expressed in axons. dendrites. and synapses in both central and peripheral nervous systems. Mice homozygous for APP or its homologue APP-like protein 2 (APLP2) null mutation (KO) are Viable, but double Mutants for APP and APLP2 deletions (DKO) are early postnatal lethal. To investigate the role of APP in synapse development, we compared the ultrastructure of submandibular ganglion synapses between DKO and littermate APLP2 KO mice at birth. Using serial electron microscopy, we found that the size of presynaptic boutons and the number of active zones per bouton were comparable in both strains of animals, However. the synaptic vesicle density, active zone size, and docked vesicle number per active zone were significantly reduced in DKO compared to those in APLP2 KO. These results indicate that the APP family of proteins plays an important role in regulating the formation and function of inter-neuronal synapses, (c) 2005 Elsevier Ireland Ltd. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER IRELAND LTD ; CLARE ; ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26997]
专题	清华大学
推荐引用方式 GB/T 7714	Yang, G,Gong, YD,Gong, K,et al. Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2[J],2010, 2010.
APA	Yang, G.,Gong, YD.,Gong, K.,Jiang, WL.,Kwon, E.,...&Zhao, NM.(2010).Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2..
MLA	Yang, G,et al."Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2".(2010).

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