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	c-Cbl mediated ubiquitination and degradation of hSef
	Ren Yong-Ming ; Rong Zhi-Li ; Li Zhi-Yong ; Cheng Long ; Li Ying-Hua ; Wang Yin-Yin ; Ren Fang-Li ; Irwin, David M. ; Chang Zhi-Jie
	2010-05-11 ; 2010-05-11
关键词	hSef c-Cbl ubiquitination degradation GROWTH-FACTOR RECEPTOR TYROSINE PHOSPHORYLATION NEGATIVE REGULATION SPROUTY PROTEINS LIGASE ACTIVITY ERK ACTIVATION SEF GENE EXPRESSION KINASES PATHWAY Biochemistry & Molecular Biology Biophysics
中文摘要	Sef (similar expression to fgf genes) was identified as a feedback antagonist of FGF signaling in zerbrafish, mouse and human. Sef has been reported to function in different ways, however the regulation of Sef stability remains unknown. The possible role of c-Cbl in the regulation of Sef protein degradation was investigated. Results from coimmunoprecipitation and immunostaining assays reveal that hSef colocalizes and interacts with c-Cbl. Data suggest that the interaction between hSef and c-Cbl results in the ubiquitination and subsequent degradation of the hSef protein. It was proposed that c-Cbl may serve as a modulator to regulate Sef protein stability during FGF signal transduction.
语种	英语 ; 英语
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS ; BEIJING ; 15 DATUN RD, CHAOYAND DISTRICT, BEIJING, 100101, PEOPLES R CHINA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26981]
专题	清华大学
推荐引用方式 GB/T 7714	Ren Yong-Ming,Rong Zhi-Li,Li Zhi-Yong,et al. c-Cbl mediated ubiquitination and degradation of hSef[J],2010, 2010.
APA	Ren Yong-Ming.,Rong Zhi-Li.,Li Zhi-Yong.,Cheng Long.,Li Ying-Hua.,...&Chang Zhi-Jie.(2010).c-Cbl mediated ubiquitination and degradation of hSef..
MLA	Ren Yong-Ming,et al."c-Cbl mediated ubiquitination and degradation of hSef".(2010).

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