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	Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation
	Huang, Huizhe ; Lu, Fu-I ; Jia, Shunji ; Meng, Shu ; Cao, Ying ; Wang, Yeqi ; Ma, Weiping ; Yin, Kun ; Wen, Zilong ; Peng, Jingrong ; Thisse, Christine ; Thisse, Bernard ; Meng, Anming
	2010-05-11 ; 2010-05-11
关键词	zebrafish epiboly convergent extension c-Src angiomotin-like2 MESODERM INDUCTION VERTEBRATE GASTRULATION CONVERGENT EXTENSION ACTS DOWNSTREAM RHO-FAMILY ANGIOMOTIN EXPRESSION PROTEINS MEMBRANE PATTERNS Developmental Biology
中文摘要	Angiomotin (Amot), the founding member of the Motin family, is involved in angiogenesis by regulating endothelial cell motility, and is required for visceral endoderm movement in mice. However, little is known about biological functions of the other two members of the Motin family, Angiomotin-like1 (Amotl1) and Angiomotin-like2 (Amotl2). Here, we have identified zebrafish amotl2 as an Fgf-responsive gene. Zebrafish amotl2 is expressed maternally and in restricted cell types zygotically. Knockdown of amotl2 expression delays epiboly and impairs convergence and extension movement, and amotl2-deficient cells in mosaic embryos fail to migrate properly. This coincides with loss of membrane protrusions and disorder of F-actin. Amotl2 partially co-localizes with RhoB- or EEA1-positive endosomes and the non-receptor tyrosine kinase c-Src. We further demonstrate that Amotl2 interacts preferentially with and facilitates outward translocation of the phosphorylated c-Src, which may in turn regulate the membrane architecture. These data provide the first evidence that amotl2 is essential for cell movements in vertebrate embryos.
语种	英语 ; 英语
出版者	COMPANY OF BIOLOGISTS LTD ; CAMBRIDGE ; BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26977]
专题	清华大学
推荐引用方式 GB/T 7714	Huang, Huizhe,Lu, Fu-I,Jia, Shunji,et al. Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation[J],2010, 2010.
APA	Huang, Huizhe.,Lu, Fu-I.,Jia, Shunji.,Meng, Shu.,Cao, Ying.,...&Meng, Anming.(2010).Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation..
MLA	Huang, Huizhe,et al."Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation".(2010).

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